| Literature DB >> 29642720 |
Tuan Anh Nguyen1, Thang Pham2, Huyen Thi Thanh Vu2, Thanh Xuan Nguyen2, Trinh Thi Vu2, Binh Thi Thanh Nguyen2, Ngoc Quynh Nguyen2, Binh Thanh Nguyen2, Binh Thanh Nguyen2, Tam Ngoc Nguyen2, Sinh Viet Phan2, Anh Trung Nguyen2, Tuan Le Pham3, Ha Thu Dang1, Lisa Kalisch-Ellett1, Marianne Gillam1, Nicole Pratt1, Sun Qiang4, Haipeng Wang4, Tipaporn Kanjanarach5, Mohamed Azmi Ahmad Hassali6, Zaheer-Ud-Din Babar7, Asrenee Ab Razak8, Dujrudee Chinwong9, Elizabeth E Roughead1.
Abstract
This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.Entities:
Keywords: anticholinergics; antipsychotics; dementia; potentially inappropriate medicines; quality use of medicines; sedatives
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Year: 2018 PMID： 29642720 DOI： 10.1177/1533317518768999
Source DB: PubMed Journal: Am J Alzheimers Dis Other Demen ISSN： 1533-3175 Impact factor: 2.035