Ahmed M El-Gendi1, Mohamed El-Shafei2, Essam Bedewy3. 1. 1 Department of Surgery, Faculty of Medicine, Alexandria University , Alexandria, Egypt . 2. 2 Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria University , Alexandria, Egypt . 3. 3 Department of Hepatology and Tropical Medicine, Faculty of Medicine, Alexandria University , Alexandria, Egypt .
Abstract
BACKGROUND: Bile leak is the main cause of morbidity and mortality after surgery for hydatid liver cysts. Aim was to assess the role of prophylactic endoscopic sphincterotomy (ES) in reducing postoperative bile leak in patients undergoing partial cystectomy. METHODS:Fifty-four patients with hepatic hydatid cyst met inclusion criteria, 27 were excluded or declined to participate. Twenty-six women and 28 men (mean age 44.6 ± 10.1, range: 22-61 years) were randomly assigned to either group I with ES (n = 27) or group II without ES (n = 27). RESULTS:Demographics and clinical, laboratory, and radiological characteristics of cysts were not statistically different between two groups. Group I had a significant decrease in bile leak rate compared with group II (11.1% versus 40.7%, P = .013), with significantly shorter duration of hospital stay (P < .0001). Biliary fistula in group I had significantly lower daily output (100 mL/day versus 350 mL/day) with gradual reduction till stoppage of leak in 3-4 days without intervention. Biliary fistula in group II had a significantly higher need for biliary intervention through postoperative endoscopic retrograde cholangiopancreatography with ES compared with biliary fistula in group I (FEP = .002), with significantly longer mean time of fistula closure (P = .011) and longer time to drain removal (P < .0001). Nonbiliary complications were comparable between two groups. CONCLUSION:Prophylactic ES provides significant reduction in postoperative bile leak ratewith shorter hospital stay after partial cystectomy of hydatid cyst. Biliary fistula in patients with ES has significantly lower daily output with shorter time of drain removal and shorter time to closure than patients without ES.
RCT Entities:
BACKGROUND: Bile leak is the main cause of morbidity and mortality after surgery for hydatid liver cysts. Aim was to assess the role of prophylactic endoscopic sphincterotomy (ES) in reducing postoperative bile leak in patients undergoing partial cystectomy. METHODS: Fifty-four patients with hepatic hydatid cyst met inclusion criteria, 27 were excluded or declined to participate. Twenty-six women and 28 men (mean age 44.6 ± 10.1, range: 22-61 years) were randomly assigned to either group I with ES (n = 27) or group II without ES (n = 27). RESULTS: Demographics and clinical, laboratory, and radiological characteristics of cysts were not statistically different between two groups. Group I had a significant decrease in bile leak rate compared with group II (11.1% versus 40.7%, P = .013), with significantly shorter duration of hospital stay (P < .0001). Biliary fistula in group I had significantly lower daily output (100 mL/day versus 350 mL/day) with gradual reduction till stoppage of leak in 3-4 days without intervention. Biliary fistula in group II had a significantly higher need for biliary intervention through postoperative endoscopic retrograde cholangiopancreatography with ES compared with biliary fistula in group I (FEP = .002), with significantly longer mean time of fistula closure (P = .011) and longer time to drain removal (P < .0001). Nonbiliary complications were comparable between two groups. CONCLUSION: Prophylactic ES provides significant reduction in postoperative bile leak rate with shorter hospital stay after partial cystectomy of hydatid cyst. Biliary fistula in patients with ES has significantly lower daily output with shorter time of drain removal and shorter time to closure than patients without ES.
Entities:
Keywords:
bile leak; endoscopic sphincterotomy; hydatid cyst; partial cystectomy
Authors: Mohammad Al-Saeedi; Ali Ramouz; Elias Khajeh; Ahmad El Rafidi; Omid Ghamarnejad; Saeed Shafiei; Sadeq Ali-Hasan-Al-Saegh; Pascal Probst; Marija Stojkovic; Tim Frederik Weber; Katrin Hoffmann; Arianeb Mehrabi Journal: PLoS Negl Trop Dis Date: 2021-05-12
Authors: Jaram Lee; Ook Song; Hyeong-Min Park; Soo Young Lee; Chang Hyun Kim; Hyeong Rok Kim Journal: Medicine (Baltimore) Date: 2021-11-19 Impact factor: 1.889