Single breath-hold 3D cardiac T1 mapping using through-time spiral GRAPPA.

The quantification of cardiac T1 relaxation time holds great potential for the detection of various cardiac diseases. However, as a result of both cardiac and respiratory motion, only one two-dimensional T1 map can be acquired in one breath-hold with most current techniques, which limits its application for whole heart evaluation in routine clinical practice. In this study, an electrocardiogram (ECG)-triggered three-dimensional Look-Locker method was developed for cardiac T1 measurement. Fast three-dimensional data acquisition was achieved with a spoiled gradient-echo sequence in combination with a stack-of-spirals trajectory and through-time non-Cartesian generalized autocalibrating partially parallel acquisition (GRAPPA) acceleration. The effects of different magnetic resonance parameters on T1 quantification with the proposed technique were first examined by simulating data acquisition and T1 map reconstruction using Bloch equation simulations. Accuracy was evaluated in studies with both phantoms and healthy subjects. These results showed that there was close agreement between the proposed technique and the reference method for a large range of T1 values in phantom experiments. In vivo studies further demonstrated that rapid cardiac T1 mapping for 12 three-dimensional partitions (spatial resolution, 2 × 2 × 8 mm3 ) could be achieved in a single breath-hold of ~12 s. The mean T1 values of myocardial tissue and blood obtained from normal volunteers at 3 T were 1311 ± 66 and 1890 ± 159 ms, respectively. In conclusion, a three-dimensional T1 mapping technique was developed using a non-Cartesian parallel imaging method, which enables fast and accurate T1 mapping of cardiac tissues in a single short breath-hold.