Ellen Elisa De Roeck1,2, Sarah Dury3,4, Nico De Witte3,5, Liesbeth De Donder3, Maria Bjerke2, Peter Paul De Deyn2,6, Sebastiaan Engelborghs2,6, Eva Dierckx1. 1. Department of Clinical and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium. 2. Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. 3. Department of Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium. 4. Research Foundation Flanders (FWO), Egmontstraat 5, 1000, Brussels, Belgium. 5. Faculty of Education, Health and Social Work, University College Ghent, Ghent, Belgium. 6. Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Hoge Beuken and Middelheim, Antwerp, Belgium.
Abstract
OBJECTIVES: Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological, social, and environmental frailty. The absence of cognitive frailty is a limitation. METHOD: An expert panel selected 6 questions from the Informant Questionnaire on Cognitive Decline that were, together with the CFAI and the Montreal cognitive assessment administered to 355 older community dwelling adults (mean age = 77). RESULTS: After multivariate analysis, 2 questions were excluded. All the questions from the original CFAI were implemented in a principal component analysis together with the 4 cognitive questions, showing that the 4 cognitive questions all load on 1 factor, representing the cognitive domain of frailty. By adding the cognitive domain to the CFAI, the reliability of the adapted CFAI (CFAI-Plus), remains good (Cronbach's alpha: .767). CONCLUSIONS: This study showed that cognitive frailty can be added to the CFAI without affecting its good psychometric properties. In the future, the CFAI-Plus needs to be validated in an independent cohort, and the interaction with the other frailty domains needs to be studied.
OBJECTIVES: Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological, social, and environmental frailty. The absence of cognitive frailty is a limitation. METHOD: An expert panel selected 6 questions from the Informant Questionnaire on Cognitive Decline that were, together with the CFAI and the Montreal cognitive assessment administered to 355 older community dwelling adults (mean age = 77). RESULTS: After multivariate analysis, 2 questions were excluded. All the questions from the original CFAI were implemented in a principal component analysis together with the 4 cognitive questions, showing that the 4 cognitive questions all load on 1 factor, representing the cognitive domain of frailty. By adding the cognitive domain to the CFAI, the reliability of the adapted CFAI (CFAI-Plus), remains good (Cronbach's alpha: .767). CONCLUSIONS: This study showed that cognitive frailty can be added to the CFAI without affecting its good psychometric properties. In the future, the CFAI-Plus needs to be validated in an independent cohort, and the interaction with the other frailty domains needs to be studied.
Authors: Therese Bittermann; Kristen Dwinnells; Sakshum Chadha; Michael S Wolf; Kim M Olthoff; Marina Serper Journal: Liver Transpl Date: 2020-10-07 Impact factor: 5.799
Authors: Deborah Lambotte; Liesbeth De Donder; Ellen E De Roeck; Lieve J Hoeyberghs; Anne van der Vorst; Daan Duppen; Michaël Van der Elst; Bram Fret; Sarah Dury; An-Sofie Smetcoren; Martinus J M Kardol; Sebastiaan Engelborghs; Peter Paul De Deyn; Nico De Witte; Jos M G A Schols; Gertrudis I J M Kempen; G A Rixt Zijlstra; Jan De Lepeleire; Birgitte Schoenmakers; Dominique Verté; Eva Dierckx Journal: BMC Geriatr Date: 2018-08-27 Impact factor: 3.921