Literature DB >> 2963637

Potential anticoagulant activity of lipocortins and other calcium/phospholipid binding proteins.

H Chap1, P Comfurius, E M Bevers, J Fauvel, P Vicendo, L Douste-Blazy, R F Zwaal.   

Abstract

Thrombin generation was determined in the presence of phospholipids, coagulation factors Xm, Vm and II (prothrombin), calcium, and various calcium/phospholipid bindings proteins, including lipocortins I and II, 35 kDa calelectrin, and 32.5 kDa endonexin. All of these proteins induced a dose-dependent inhibition of thrombin generation similar to the inhibition of pig pancreas phospholipase A2. It is suggested that the ability of lipocortins and other related proteins to interact with anionic phospholipids in the presence of Ca++ is responsible for both their anticoagulant and anti-phospholipase A2 activity.

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Year:  1988        PMID： 2963637     DOI： 10.1016/0006-291x(88)90724-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

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Authors:  J Römisch; E P Pâques
Journal:  Med Microbiol Immunol       Date:  1991       Impact factor: 3.402

2.  A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation.

Authors:  B Rothhut; C Coméra; S Cortial; P Y Haumont; K H Diep Le; J C Cavadore; J Conard; F Russo-Marie; F Lederer
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

3.  Annexin 5 as a potential regulator of annexin 1 phosphorylation by protein kinase C. In vitro inhibition compared with quantitative data on annexin distribution in human endothelial cells.

Authors:  P Raynal; F Hullin; J M Ragab-Thomas; J Fauvel; H Chap
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

4.  Inhibition of intraocular fibrin formation with annexin V.

Authors:  P Chollet; F Malecaze; F Hullin; P Raynal; J L Arne; V Pagot; J Ragab-Thomas; H Chap
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5.  A purified lipocortin shares the anti-inflammatory effect of glucocorticosteroids in vivo in mice.

Authors:  M Errasfa; F Russo-Marie
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

6.  Detection, purification and identification of an endogenous inhibitor of L-Dopa decarboxylase activity from human placenta.

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Authors:  Elena Y Senchenkova; Junaid Ansari; Felix Becker; Shantel A Vital; Zaki Al-Yafeai; Erica M Sparkenbaugh; Rafal Pawlinski; Karen Y Stokes; Jennifer L Carroll; Ana-Maria Dragoi; Cheng Xue Qin; Rebecca H Ritchie; Hai Sun; Hugo H Cuellar-Saenz; Mara R Rubinstein; Yiping W Han; A Wayne Orr; Mauro Perretti; D Neil Granger; Felicity N E Gavins
Journal:  Circulation       Date:  2019-06-03       Impact factor: 29.690

Review 8.  Phosphatidylserine is an overlooked mediator of COVID-19 thromboinflammation.

Authors:  Stuart E Lind
Journal:  Heliyon       Date:  2021-01-20
  8 in total

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