Daniel Gero1, Robert E Steinert1, Hanna Hosa1, David E Cummings2, Marco Bueter3. 1. Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland. 2. Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA. 3. Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland marco.bueter@usz.ch.
Abstract
OBJECTIVE: To examine the effect of different feeding routes on appetite and metabolic responses after Roux-en-Y gastric bypass (RYGB). RESEARCH DESIGN AND METHODS: A standard liquid meal was administered either orally, into the gastric remnant, or intraduodenally 6 months after RYGB. Changes in plasma glucose, insulin, glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), peptide YY (PYY), and appetite were measured pre- and postprandially. RESULTS: Postprandial GLP-1 and PYY responses were similar, whereas glucose, insulin, and GIP levels differed markedly after oral versus intraduodenal feeding. Intraduodenal feeding prompted an intermediate appetite response (i.e., between oral and intragastric). For postprandial glucose, insulin, and GIP levels, the intraduodenal route was more similar to the intragastric than the oral route. Intragastric administration did not evoke changes in appetite, glucose, or insulin; however, it slightly increased GLP-1 and PYY and moderately increased GIP. CONCLUSIONS: Appetite and metabolic responses after RYGB depend on the route by which nutrients enter the gastrointestinal tract.
OBJECTIVE: To examine the effect of different feeding routes on appetite and metabolic responses after Roux-en-Y gastric bypass (RYGB). RESEARCH DESIGN AND METHODS: A standard liquid meal was administered either orally, into the gastric remnant, or intraduodenally 6 months after RYGB. Changes in plasma glucose, insulin, glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), peptide YY (PYY), and appetite were measured pre- and postprandially. RESULTS: Postprandial GLP-1 and PYY responses were similar, whereas glucose, insulin, and GIP levels differed markedly after oral versus intraduodenal feeding. Intraduodenal feeding prompted an intermediate appetite response (i.e., between oral and intragastric). For postprandial glucose, insulin, and GIP levels, the intraduodenal route was more similar to the intragastric than the oral route. Intragastric administration did not evoke changes in appetite, glucose, or insulin; however, it slightly increased GLP-1 and PYY and moderately increased GIP. CONCLUSIONS: Appetite and metabolic responses after RYGB depend on the route by which nutrients enter the gastrointestinal tract.
Authors: Aiman Ismaeil; Daniel Gero; Christina N Boyle; Daniela Alceste; Osama Taha; Alan C Spector; Thomas A Lutz; Marco Bueter Journal: Front Nutr Date: 2022-04-13
Authors: Daniel Gero; Bálint File; Daniela Alceste; Lukas D Frick; Michele Serra; Aiman Em Ismaeil; Robert E Steinert; Alan C Spector; Marco Bueter Journal: JCI Insight Date: 2021-08-09