Literature DB >> 29636181

Antigen processing and presentation in HIV infection.

Julie Boucau1, Sylvie Le Gall2.   

Abstract

The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV; Immune escape; Immunopeptidome; Protein degradation; T cells; Vaccine immunogen design

Mesh：

Substances：

Year:  2018        PMID： 29636181      PMCID： PMC6174111          DOI： 10.1016/j.molimm.2018.03.027

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  165 in total

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Authors:  O Schwartz; V Maréchal; S Le Gall; F Lemonnier; J M Heard
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Authors:  Srinika R F Ranasinghe; Holger B Kramer; Cynthia Wright; Benedikt M Kessler; Katalin di Gleria; Yonghong Zhang; Geraldine M Gillespie; Marie-Eve Blais; Abigail Culshaw; Tica Pichulik; Alison Simmons; Sarah L Rowland-Jones; Andrew J McMichael; Tao Dong
Journal:  PLoS Pathog       Date:  2011-05-12       Impact factor: 6.823

10.  Impact of pre-adapted HIV transmission.

Authors:  Jonathan M Carlson; Victor Y Du; Nico Pfeifer; Anju Bansal; Vincent Y F Tan; Karen Power; Chanson J Brumme; Anat Kreimer; Charles E DeZiel; Nicolo Fusi; Malinda Schaefer; Mark A Brockman; Jill Gilmour; Matt A Price; William Kilembe; Richard Haubrich; Mina John; Simon Mallal; Roger Shapiro; John Frater; P Richard Harrigan; Thumbi Ndung'u; Susan Allen; David Heckerman; John Sidney; Todd M Allen; Philip J R Goulder; Zabrina L Brumme; Eric Hunter; Paul A Goepfert
Journal:  Nat Med       Date:  2016-05-16       Impact factor: 53.440
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