Lies Van Assche1, Evelyne Van Aubel1, Lucas Van de Ven1, Filip Bouckaert1, Patrick Luyten2,3, Mathieu Vandenbulcke1. 1. Section of Old Age Psychiatry, Department of Psychiatry, University Hospitals Leuven, KUL, Leuven, Belgium. 2. Department of Psychology, University of Leuven, Leuven, Belgium. 3. Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Abstract
OBJECTIVE: Late onset psychosis not only occurs as a prodromal symptom to neurodegeneration, but it can also be associated with a non-progressive mild cognitive deficit. Studying the phenomenology of psychotic symptoms and the neuropsychological profile may serve as sensitive and non-invasive tools for differential diagnosis. METHOD: We compared 57 individuals with very-late-onset schizophrenia-like psychosis (VLOSLP), 49 participants with Dementia with Lewy Bodies (DLB) and 35 patients with Alzheimer's type Dementia and psychosis (AD+P) concerning the phenomenology of psychotic symptoms and the neuropsychological profile using several measures of cognitive function in a cross-sectional study. RESULTS: Participants with DLB exhibited more visual hallucinations, especially those involving animals, and less partition/paranoid delusions than both other groups. VLOSLP showed more partition delusions and auditory hallucinations of human voices than both other groups. Hence, patients with DLB and VLOSLP showed greater dissimilarity in the phenomenology of psychosis, whereas individuals with AD+P held an intermediate position. Processing speed and executive function were comparably impaired among the three groups, as was expected considering a common underlying set of neurobiological abnormalities for psychosis. However, AD+P showed more strongly reduced learning and consolidation skills, whereas DLB was associated with prominent visuoconstructive deficits. CONCLUSIONS: Phenomenology of psychosis may prove especially informative when comparing individuals with DLB to those with VLOSLP. Neuropsychological profiles are able to further aid differential diagnosis of the three groups.
OBJECTIVE: Late onset psychosis not only occurs as a prodromal symptom to neurodegeneration, but it can also be associated with a non-progressive mild cognitive deficit. Studying the phenomenology of psychotic symptoms and the neuropsychological profile may serve as sensitive and non-invasive tools for differential diagnosis. METHOD: We compared 57 individuals with very-late-onset schizophrenia-like psychosis (VLOSLP), 49 participants with Dementia with Lewy Bodies (DLB) and 35 patients with Alzheimer's type Dementia and psychosis (AD+P) concerning the phenomenology of psychotic symptoms and the neuropsychological profile using several measures of cognitive function in a cross-sectional study. RESULTS: Participants with DLB exhibited more visual hallucinations, especially those involving animals, and less partition/paranoid delusions than both other groups. VLOSLP showed more partition delusions and auditory hallucinations of human voices than both other groups. Hence, patients with DLB and VLOSLP showed greater dissimilarity in the phenomenology of psychosis, whereas individuals with AD+P held an intermediate position. Processing speed and executive function were comparably impaired among the three groups, as was expected considering a common underlying set of neurobiological abnormalities for psychosis. However, AD+P showed more strongly reduced learning and consolidation skills, whereas DLB was associated with prominent visuoconstructive deficits. CONCLUSIONS: Phenomenology of psychosis may prove especially informative when comparing individuals with DLB to those with VLOSLP. Neuropsychological profiles are able to further aid differential diagnosis of the three groups.
Authors: Catherine A Brownstein; Richard S Smith; Lance H Rodan; Mark P Gorman; Margaret A Hojlo; Emily A Garvey; Jianqiao Li; Kristin Cabral; Joshua J Bowen; Abhijit S Rao; Casie A Genetti; Devon Carroll; Emma A Deaso; Pankaj B Agrawal; Jill A Rosenfeld; Weimin Bi; Jennifer Howe; Dimitri J Stavropoulos; Adam W Hansen; Hesham M Hamoda; Ferne Pinard; Annmarie Caracansi; Christopher A Walsh; Eugene J D'Angelo; Alan H Beggs; Mehdi Zarrei; Richard A Gibbs; Stephen W Scherer; David C Glahn; Joseph Gonzalez-Heydrich Journal: Mol Psychiatry Date: 2021-02-17 Impact factor: 15.992
Authors: Alexandre González-Rodríguez; Mary V Seeman; Eduard Izquierdo; Mentxu Natividad; Armand Guàrdia; Eloïsa Román; José A Monreal Journal: Int J Environ Res Public Health Date: 2022-06-28 Impact factor: 4.614
Authors: Ian G McKeith; Tanis J Ferman; Alan J Thomas; Frédéric Blanc; Bradley F Boeve; Hiroshige Fujishiro; Kejal Kantarci; Cristina Muscio; John T O'Brien; Ronald B Postuma; Dag Aarsland; Clive Ballard; Laura Bonanni; Paul Donaghy; Murat Emre; James E Galvin; Douglas Galasko; Jennifer G Goldman; Stephen N Gomperts; Lawrence S Honig; Manabu Ikeda; James B Leverenz; Simon J G Lewis; Karen S Marder; Mario Masellis; David P Salmon; John Paul Taylor; Debby W Tsuang; Zuzana Walker; Pietro Tiraboschi Journal: Neurology Date: 2020-04-02 Impact factor: 9.910
Authors: Kiwon Kim; Hong Jin Jeon; Woojae Myung; Seung Wan Suh; Su Jeong Seong; Jae Yeon Hwang; Je Il Ryu; Seon-Cheol Park Journal: J Pers Med Date: 2022-03-02