Literature DB >> 29633972

High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase.

Kang Zhou1, Xiaojiao Fan1, Yuelong Li1, Caiying Zhang1, Tengchuan Jin1.   

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that plays critical roles in bacterial pathogenesis in some pathogenic bacteria. In this study, the crystal structure of group B streptococcus GAPDH was determined at 1.36 Å resolution. The structure contained an asymmetric mixed holo tetramer, with two NAD ligands bound to two protomers. Further structural analysis identified interesting phosphate ion-binding sites, which shed light on its catalytic mechanism.

Entities:  

Keywords:  NAD; Streptococcus agalactiae; asymmetric tetramer; glyceraldehyde-3-phosphate dehydrogenase; group B streptococcus; phosphate-binding sites

Mesh：

Substances：

Year:  2018        PMID： 29633972      PMCID： PMC5894109          DOI： 10.1107/S2053230X18003801

Source DB:  PubMed          Journal:  Acta Crystallogr F Struct Biol Commun        ISSN： 2053-230X            Impact factor:   1.056


  33 in total

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3.  XDS.

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Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2010-01-22

4.  Processing of X-ray diffraction data collected in oscillation mode.

Authors:  Z Otwinowski; W Minor
Journal:  Methods Enzymol       Date:  1997       Impact factor: 1.600

5.  Association between low concentrations of antibodies to protein alpha and Rib and invasive neonatal group B streptococcal infection.

Authors:  C Larsson; M Lindroth; P Nordin; M Stålhammar-Carlemalm; G Lindahl; I Krantz
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2006-11       Impact factor: 5.747

6.  Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.

Authors:  Polina V Danshina; Weidong Qu; Brenda R Temple; Rafael J Rojas; Michael J Miley; Mischa Machius; Laurie Betts; Deborah A O'Brien
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Review 7.  Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy.

Authors:  Kelly S Doran; Victor Nizet
Journal:  Mol Microbiol       Date:  2004-10       Impact factor: 3.501

8.  Diversity of surface protein expression in group B streptococcal colonizing & invasive isolates.

Authors:  P Ferrieri; C J Baker; S L Hillier; A E Flores
Journal:  Indian J Med Res       Date:  2004-05       Impact factor: 2.375

9.  A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice.

Authors:  Joana Alves; Pedro Madureira; Maria Teresa Baltazar; Leandro Barros; Liliana Oliveira; Ricardo Jorge Dinis-Oliveira; Elva Bonifácio Andrade; Adília Ribeiro; Luís Mira Vieira; Patrick Trieu-Cuot; José Alberto Duarte; Félix Carvalho; Paula Ferreira
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10.  Phaser crystallographic software.

Authors:  Airlie J McCoy; Ralf W Grosse-Kunstleve; Paul D Adams; Martyn D Winn; Laurent C Storoni; Randy J Read
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  2 in total

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Authors:  Matthew J Sullivan; Kelvin G K Goh; Ruby Thapa; Debasish Chattopadhyay; Deepak S Ipe; Benjamin L Duell; Lahiru Katupitiya; Dean Gosling; Dhruba Acharya; Glen C Ulett
Journal:  Virulence       Date:  2021-12       Impact factor: 5.882

2.  Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH-Novel Heme Acquisition Strategy in the Oral Microbiome.

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  2 in total

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