Literature DB >> 29633780

Refolding of helical soluble α-synuclein through transient interaction with lipid interfaces.

Matteo Rovere1, John B Sanderson1, Luis Fonseca-Ornelas1, Dushyant S Patel1, Tim Bartels1.   

Abstract

α-Synuclein (αSyn) is a key player in the pathogenesis of Parkinson's disease and other synucleinopathies. Here, we report the existence of a novel soluble α-helical conformer of αSyn, obtained through transient interaction with lipid interfaces, and propose dynamic oligomerization as the mechanism underlying its stability. The conformational space of αSyn appears to be highly context-dependent, and lipid bilayers might thus play crucial roles as molecular chaperones in a cellular environment.
© 2018 Federation of European Biochemical Societies.

Entities:  

Keywords:  Parkinson's disease; intrinsically disordered proteins; protein folding; small unilamellar vesicles; α-synuclein

Mesh：

Substances：

Year:  2018        PMID： 29633780     DOI： 10.1002/1873-3468.13047

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

Review 1.  Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration.

Authors:  Fred Yeboah; Tae-Eun Kim; Anke Bill; Ulf Dettmer
Journal:  Neurobiol Dis       Date:  2019-07-24       Impact factor: 5.996

Review 2.  Parkinson's disease: proteinopathy or lipidopathy?

Authors:  Saranna Fanning; Dennis Selkoe; Ulf Dettmer
Journal:  NPJ Parkinsons Dis       Date:  2020-01-03

3.  Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.

Authors:  Maria Ericsson; Victoria von Saucken; Andrew J Newman; Lena Doehr; Camilla Hoesch; Tae-Eun Kim; Ulf Dettmer
Journal:  Brain Res       Date:  2021-02-09       Impact factor: 3.252

Review 4.  Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease.

Authors:  Ulf Dettmer
Journal:  Front Neurosci       Date:  2018-09-25       Impact factor: 4.677

Review 5.  Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.

Authors:  Richard M Meade; David P Fairlie; Jody M Mason
Journal:  Mol Neurodegener       Date:  2019-07-22       Impact factor: 14.195

Review 6.  Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation.

Authors:  Heather R Lucas; Ricardo D Fernández
Journal:  Neural Regen Res       Date:  2020-03       Impact factor: 5.135

Review 7.  Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk.

Authors:  Rakez Kayed; Ulf Dettmer; Sylvain E Lesné
Journal:  J Parkinsons Dis       Date:  2020       Impact factor: 5.568

8.  Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.

Authors:  Thibaut Imberdis; Joseph Negri; Nagendran Ramalingam; Elizabeth Terry-Kantor; Gary P H Ho; Saranna Fanning; Georgia Stirtz; Tae-Eun Kim; Oren A Levy; Tracy L Young-Pearse; Dennis Selkoe; Ulf Dettmer
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-23       Impact factor: 11.205

9.  Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

Authors:  John B Sanderson; Suman De; Haiyang Jiang; Matteo Rovere; Ming Jin; Ludovica Zaccagnini; Aurelia Hays Watson; Laura De Boni; Valentina N Lagomarsino; Tracy L Young-Pearse; Xinyue Liu; Thomas C Pochapsky; Bradley T Hyman; Dennis W Dickson; David Klenerman; Dennis J Selkoe; Tim Bartels
Journal:  Brain Commun       Date:  2020-02-11

Review 10.  Parkinson's disease: proteinopathy or lipidopathy?

Authors:  Saranna Fanning; Dennis Selkoe; Ulf Dettmer
Journal:  NPJ Parkinsons Dis       Date:  2020-01-03
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