Yinji Liang1, Chenli Lin2, Yupei Zhang3, Yuanjun Deng3, Chan Liu2, Qinhe Yang4. 1. School of Nursing, Jinan University, 601 Huangpu Road West, Guangzhou, 510632, Guangdong, China. 2. School of Basic Medicine, Jinan University, 601 Huangpu Road West, Guangzhou, 510632, Guangdong, China. 3. School of Traditional Chinese Medicine, Jinan University, 601 Huangpu Road West, Guangzhou, 510632, Guangdong, China. 4. School of Traditional Chinese Medicine, Jinan University, 601 Huangpu Road West, Guangzhou, 510632, Guangdong, China. tyangqh@jnu.edu.cn.
Abstract
AIMS: The study explored the systemic adiposity and inflammation through Gpr109a and the commensal metabolite butyrate during the treatment of non-alcoholic fatty liver disease rats with the probiotic mixture of Lactobacillus and Bifidobacterium for 16 weeks. METHODS: Fifteen male SD rats were randomly divided into three groups of five rats each: normal control group (basal feed), high-fat diet (HFD) feeding group (83% basal feed + 10% lard oil + 5% sucrose + 1.5% cholesterol + 0.5% cholate), and probiotic mixture intervention group (HFD + 0.6 g kg-1 day-1 probiotic mixture). Body composition, serum lipids, serum inflammatory markers, Gpr109a, and the commensal metabolite butyrate were assessed. RESULTS: Compared with HFD group, probiotic mixture significantly reduced body weight and the levels of serum FFA, TG, ALT, IL-1β, and IL-18 (P < 0.05). The levels of Gpr109a and the commensal metabolite butyrate also changed significantly (P < 0.05). CONCLUSIONS: Probiotic mixture might inhibit systemic adiposity and inflammation through Gpr109a and the commensal metabolite butyrate in response to the insult of HFD.
AIMS: The study explored the systemic adiposity and inflammation through Gpr109a and the commensal metabolite butyrate during the treatment of non-alcoholic fatty liver diseaserats with the probiotic mixture of Lactobacillus and Bifidobacterium for 16 weeks. METHODS: Fifteen male SD rats were randomly divided into three groups of five rats each: normal control group (basal feed), high-fat diet (HFD) feeding group (83% basal feed + 10% lard oil + 5% sucrose + 1.5% cholesterol + 0.5% cholate), and probiotic mixture intervention group (HFD + 0.6 g kg-1 day-1 probiotic mixture). Body composition, serum lipids, serum inflammatory markers, Gpr109a, and the commensal metabolite butyrate were assessed. RESULTS: Compared with HFD group, probiotic mixture significantly reduced body weight and the levels of serum FFA, TG, ALT, IL-1β, and IL-18 (P < 0.05). The levels of Gpr109a and the commensal metabolite butyrate also changed significantly (P < 0.05). CONCLUSIONS: Probiotic mixture might inhibit systemic adiposity and inflammation through Gpr109a and the commensal metabolite butyrate in response to the insult of HFD.
Authors: Sorin Tunaru; Jukka Kero; Annette Schaub; Christian Wufka; Andree Blaukat; Klaus Pfeffer; Stefan Offermanns Journal: Nat Med Date: 2003-02-03 Impact factor: 53.440
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