Literature DB >> 29632576

Ghrelin - Physiological Functions and Regulation.

Mona Mohamed Ibrahim Abdalla1.   

Abstract

Ghrelin is an orexigenic peptide predominantly secreted from the stomach and stimulates appetite and growth hormone (GH) release. Studies have provided evidence that ghrelin exercises a wide range of functions, including regulation of food intake and energy metabolism, modulation of cardiovascular function, stimulation of osteoblast proliferation and bone formation and stimulation of neurogenesis and myogenesis. In the gastrointestinal system, ghrelin affects multiple functions, including secretion of gastric acid, gastric motility and pancreatic protein output. Most of these functions have been attributed to the actions of acylated ghrelin. The balance among its secretion rate, degradation rate and clearance rate determines the circulating level of ghrelin. This review explains what ghrelin is, its physiological functions and the factors that influence its level.

Entities:  

Keywords:  Ghrelin; food intake; ghrelin receptors; lipolysis; obesity; regulation

Year:  2015        PMID： 29632576      PMCID： PMC5819073          DOI： 10.17925/EE.2015.11.02.90

Source DB:  PubMed          Journal:  Eur Endocrinol        ISSN： 1758-3772


  117 in total

1.  Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep.

Authors:  Toshihisa Sugino; Junji Yamaura; Masako Yamagishi; Yohei Kurose; Masayasu Kojima; Kenji Kangawa; Yoshihisa Hasegawa; Yoshiaki Terashima
Journal:  Biochem Biophys Res Commun       Date:  2003-05-02       Impact factor: 3.575

2.  Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor.

Authors:  Birgitte Holst; Manja Lang; Erik Brandt; Anders Bach; Andrew Howard; Thomas M Frimurer; Annette Beck-Sickinger; Thue W Schwartz
Journal:  Mol Pharmacol       Date:  2006-06-23       Impact factor: 4.436

3.  A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.

Authors:  D E Cummings; J Q Purnell; R S Frayo; K Schmidova; B E Wisse; D S Weigle
Journal:  Diabetes       Date:  2001-08       Impact factor: 9.461

4.  Establishment of a novel ghrelin-producing cell line.

Authors:  Hiroshi Iwakura; Yushu Li; Hiroyuki Ariyasu; Hiroshi Hosoda; Naotetsu Kanamoto; Mika Bando; Go Yamada; Kiminori Hosoda; Kazuwa Nakao; Kenji Kangawa; Takashi Akamizu
Journal:  Endocrinology       Date:  2010-04-07       Impact factor: 4.736

5.  Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

Authors:  Tong-Jin Zhao; Guosheng Liang; Robert Lin Li; Xuefen Xie; Mark W Sleeman; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Joseph L Goldstein; Michael S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-15       Impact factor: 11.205

6.  Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure.

Authors:  Noritoshi Nagaya; Junji Moriya; Yoshio Yasumura; Masaaki Uematsu; Fumiaki Ono; Wataru Shimizu; Kazuyuki Ueno; Masafumi Kitakaze; Kunio Miyatake; Kenji Kangawa
Journal:  Circulation       Date:  2004-11-29       Impact factor: 29.690

7.  Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli.

Authors:  Chi-Bun Chan; Christopher H K Cheng
Journal:  Mol Cell Endocrinol       Date:  2004-02-12       Impact factor: 4.102

8.  Ghrelin-a new gastroprotective factor in gastric mucosa.

Authors:  P C Konturek; T Brzozowski; R Pajdo; A Nikiforuk; S Kwiecien; I Harsch; D Drozdowicz; E G Hahn; S J Konturek
Journal:  J Physiol Pharmacol       Date:  2004-06       Impact factor: 3.011

9.  Growth hormone (GH) responses to the combined administration of GH-releasing hormone plus GH-releasing peptide 6 in adults with GH deficiency.

Authors:  A Leal-Cerro; E Garcia; R Astorga; F F Casanueva; C Dieguez
Journal:  Eur J Endocrinol       Date:  1995-06       Impact factor: 6.664

10.  Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.

Authors:  Ligen Lin; Pradip K Saha; Xiaojun Ma; Iyabo O Henshaw; Longjiang Shao; Benny H J Chang; Eric D Buras; Qiang Tong; Lawrence Chan; Owen P McGuinness; Yuxiang Sun
Journal:  Aging Cell       Date:  2011-10-12       Impact factor: 9.304
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  20 in total

1.  The Association Between Salivary Ghrelin Levels with Anthropometric Measures in Underweight, Normal, Overweight and Obese Healthy Adult Males.

Authors:  Mona Mohamed Ibrahim Abdalla; Soon Siew Choo
Journal:  Eur Endocrinol       Date:  2020-02-28

2.  Potential Role of Hypothalamic and Plasma Ghrelin in the Feeding Behavior of Obese Type 2 Diabetic Rats with Intraventricular Glucagon-Like Peptide-1 Receptor Agonist Intervention.

Authors:  Ke Lu; Xiaoyan Chen; Xuelian Deng; Juan Long; Jianhua Yan
Journal:  Obes Facts       Date:  2020-12-18       Impact factor: 3.942

Review 3.  Genetic variation in satiety signaling and hypothalamic inflammation: merging fields for the study of obesity.

Authors:  Alexandria Maria Szalanczy; Chia-Chi Chuang Key; Leah Catherine Solberg Woods
Journal:  J Nutr Biochem       Date:  2021-12-20       Impact factor: 6.048

Review 4.  Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases.

Authors:  Orkid Coskuner-Weber; Ozan Mirzanli; Vladimir N Uversky
Journal:  Biophys Rev       Date:  2022-06-08

Review 5.  Are the Changes in Gastrointestinal Hormone Secretion Necessary for the Success of Bariatric Surgery? A Critical Review of the Literature.

Authors:  Charalampos Lampropoulos; Theodoros Alexandrides; Stylianos Tsochatzis; Dimitrios Kehagias; Ioannis Kehagias
Journal:  Obes Surg       Date:  2021-07-25       Impact factor: 4.129

6.  The role of age in the physiological adaptations and psychological responses in bikini-physique competitor contest preparation: a case series.

Authors:  Daniel E Newmire; Heather E Webb
Journal:  J Int Soc Sports Nutr       Date:  2021-06-09       Impact factor: 5.150

Review 7.  A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications.

Authors:  Kiall F Suazo; Keun-Young Park; Mark D Distefano
Journal:  Chem Rev       Date:  2021-04-06       Impact factor: 72.087

Review 8.  Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.

Authors:  Andreas Stengel; Yvette Taché
Journal:  Front Endocrinol (Lausanne)       Date:  2018-08-28       Impact factor: 5.555

Review 9.  MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.

Authors:  René Klinkby Støving
Journal:  Eur J Endocrinol       Date:  2019-01-01       Impact factor: 6.664

10.  Ghrelin as a possible biomarker and maintaining factor in patients with eating disorders reporting childhood traumatic experiences.

Authors:  Eleonora Rossi; Emanuele Cassioli; Veronica Gironi; Eglantina Idrizaj; Rachele Garella; Roberta Squecco; Maria Caterina Baccari; Mario Maggi; Linda Vignozzi; Paolo Comeglio; Valdo Ricca; Giovanni Castellini
Journal:  Eur Eat Disord Rev       Date:  2021-05-03
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