| Literature DB >> 29632329 |
Quirin Hammer1, Timo Rückert1, Eva Maria Borst2, Josefine Dunst3, André Haubner1, Pawel Durek4,5, Frederik Heinrich6, Gilles Gasparoni7, Marina Babic1, Adriana Tomic2, Gabriella Pietra8,9, Mikalai Nienen10, Igor Wolfgang Blau11, Jörg Hofmann12,13, Il-Kang Na11,14,15, Immo Prinz16, Christian Koenecke16,17, Philipp Hemmati11, Nina Babel10,18, Renate Arnold11, Jörn Walter7, Kevin Thurley19, Mir-Farzin Mashreghi6, Martin Messerle2, Chiara Romagnani20,21.
Abstract
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C+ NK cells differentially recognized distinct HCMV strains encoding variable UL40 peptides that, in combination with pro-inflammatory signals, controlled the population expansion and differentiation of adaptive NKG2C+ NK cells. Thus, we propose that polymorphic HCMV peptides contribute to shaping of the heterogeneity of adaptive NKG2C+ NK cell populations among HCMV-seropositive people.Entities:
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Year: 2018 PMID： 29632329 DOI： 10.1038/s41590-018-0082-6
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606