Jisun Paik1, Piper M Treuting2, Michael Haenisch2, John K Amory3. 1. Department of Comparative Medicine, University of Washington, Seattle, WA, USA. Electronic address: jpaik@uw.edu. 2. Department of Comparative Medicine, University of Washington, Seattle, WA, USA. 3. Department of Medicine, University of Washington, Seattle, WA, USA.
Abstract
OBJECTIVE: Vitamin A deficient females have reduced fertility due to decreased retinoic acid production. WIN 18,446 inhibits retinoic acid biosynthesis and functions as a contraceptive in males. We tested whether WIN 18,446 treatment would suppress fertility in female mice. STUDY DESIGN: Female mice were treated with WIN 18,446 and mated. Pregnancy rates were compared using Fisher's exact test. RESULTS: WIN 18,446 reduced pregnancy compared with control (p=.03). However, one animal became pregnant with malformed embryos. CONCLUSIONS: WIN 18,446 treatment significantly reduces fecundity, but teratogenicity in the setting of contraceptive failure limits the appeal of this approach to female contraception.
OBJECTIVE:Vitamin A deficient females have reduced fertility due to decreased retinoic acid production. WIN 18,446 inhibits retinoic acid biosynthesis and functions as a contraceptive in males. We tested whether WIN 18,446 treatment would suppress fertility in female mice. STUDY DESIGN: Female mice were treated with WIN 18,446 and mated. Pregnancy rates were compared using Fisher's exact test. RESULTS: WIN 18,446 reduced pregnancy compared with control (p=.03). However, one animal became pregnant with malformed embryos. CONCLUSIONS: WIN 18,446 treatment significantly reduces fecundity, but teratogenicity in the setting of contraceptive failure limits the appeal of this approach to female contraception.
Authors: R Le Bouffant; M J Guerquin; C Duquenne; N Frydman; H Coffigny; V Rouiller-Fabre; R Frydman; R Habert; G Livera Journal: Hum Reprod Date: 2010-07-29 Impact factor: 6.918
Authors: Jisun Paik; Michael Haenisch; Charles H Muller; Alex S Goldstein; Samuel Arnold; Nina Isoherranen; Thea Brabb; Piper M Treuting; John K Amory Journal: J Biol Chem Date: 2014-04-07 Impact factor: 5.157
Authors: John K Amory; Charles H Muller; Jakob A Shimshoni; Nina Isoherranen; Jisun Paik; Jan S Moreb; David W Amory; Ryan Evanoff; Alex S Goldstein; Michael D Griswold Journal: J Androl Date: 2010-08-12