Literature DB >> 29629713

Immunometabolism: Itaconate helps KEAP1's cool.

Grant Otto.   

Abstract

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Year:  2018        PMID： 29629713     DOI： 10.1038/nri.2018.27

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


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  1 in total

1.  Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Authors:  Evanna L Mills; Dylan G Ryan; Hiran A Prag; Dina Dikovskaya; Deepthi Menon; Zbigniew Zaslona; Mark P Jedrychowski; Ana S H Costa; Maureen Higgins; Emily Hams; John Szpyt; Marah C Runtsch; Martin S King; Joanna F McGouran; Roman Fischer; Benedikt M Kessler; Anne F McGettrick; Mark M Hughes; Richard G Carroll; Lee M Booty; Elena V Knatko; Paul J Meakin; Michael L J Ashford; Louise K Modis; Gino Brunori; Daniel C Sévin; Padraic G Fallon; Stuart T Caldwell; Edmund R S Kunji; Edward T Chouchani; Christian Frezza; Albena T Dinkova-Kostova; Richard C Hartley; Michael P Murphy; Luke A O'Neill
Journal:  Nature       Date:  2018-03-28       Impact factor: 49.962
  1 in total
  2 in total

1.  4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.

Authors:  Shan-Ting Liao; Chao Han; Ding-Qiao Xu; Xiao-Wei Fu; Jun-Song Wang; Ling-Yi Kong
Journal:  Nat Commun       Date:  2019-11-08       Impact factor: 14.919

2.  Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS.

Authors:  Xiaoyang Zhu; Yangyang Guo; Zhigang Liu; Jingyi Yang; Huiru Tang; Yulan Wang
Journal:  Sci Rep       Date:  2021-09-13       Impact factor: 4.379
  2 in total

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