| Literature DB >> 29629626 |
Ying Peng1,2, Yan Li1,2, Yonghong He1,2, Qinglin Wei1,2, Qiaoling Xie1,2, Liangjun Zhang1,2, Yiju Xia1,2, Xueqian Zhou1,2, Lu Zhang1,2, Xinchan Feng1,2, Kun Chen2, Sheng Chen3, Wensheng Chen1,2, Qinglin Long2, Jin Chai1,2.
Abstract
INTRODUCTION: Neutrophil to lymphocyte ratio (NLR) is widely used to assess inflammatory diseases. We performed a systematic review to explore the prognostic role of NLR for the assessment of liver fibrosis and cirrhosis. Areas covered: We searched the PubMed and EMBASE databases for the eligible papers which explored the association between NLR and liver fibrosis/cirrhosis or investigated the prognostic value of NLR in cirrhotic patients. Expert commentary: In accordance with assessment of liver fibrosis stage, we classified papers into four subgroups by etiology. For the patients with nonalcoholic fatty liver disease (NAFLD) there was a significant association between NLR and fibrosis stage and nonalcoholic fatty liver disease activity score (NAS), while NLR had a negative correlation with fibrosis stage for the patients with chronic hepatitis B (CHB). As for the patients with and chronic hepatitis C (CHC), NLR might not be significantly associated with fibrosis stage. Moreover, NLR seemed to be significantly useful for predicting outcomes in cirrhotic patients. Hence, NLR might be associated with liver fibrosis stage, especially in patients with NAFLD. Furthermore, NLR might be a useful biomarker for evaluating the prognosis in cirrhotic patients.Entities:
Keywords: Liver cirrhosis; liver fibrosis; neutrophil to lymphocyte ratio; nonalcoholic fatty liver disease; prognosis
Mesh：
Year: 2018 PMID： 29629626 DOI： 10.1080/17474124.2018.1463158
Source DB: PubMed Journal: Expert Rev Gastroenterol Hepatol ISSN： 1747-4124 Impact factor: 3.869