Literature DB >> 2962885

Starvation or diabetes decreases the content but not the mRNA of 6-phosphofructo-2-kinase in rat liver.

K M Crepin1, M I Darville, L Hue, G G Rousseau.   

Abstract

In rat liver, the activity of 6-phosphofructo-2-kinase (PFK-2) decreases upon starvation and in diabetes. Cyclic AMP-dependent phosphorylation of the enzyme is not sufficient to account for this decrease. PFK-2 content was therefore measured by immunotitration and relative PFK-2 mRNA levels were determined by hybridization with cDNA probes. The data are compatible with a posttranscriptional mechanism of regulation that involves decreased translational efficiency of PFK-2 mRNA and (or) increased turnover of the PFK-2 protein.

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Year:  1988        PMID： 2962885     DOI： 10.1016/0014-5793(88)80884-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  5' flanking sequence and structure of a gene encoding rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Authors:  M I Darville; K M Crepin; L Hue; G G Rousseau
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

2.  Expression of the liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA in FAO-1 cells.

Authors:  C Espinet; A M Vargas; M R el-Maghrabi; A J Lange; S J Pilkis
Journal:  Biochem J       Date:  1993-07-01       Impact factor: 3.857

Review 3.  Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver.

Authors:  F P Lemaigre; G G Rousseau
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

4.  Phosphofructokinase 2 and glycolysis in HT29 human colon adenocarcinoma cell line. Regulation by insulin and phorbol esters.

Authors:  C Denis-Pouxviel; T Gauthier; D Daviaud; J C Murat
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

5.  Cloning and expression in Escherichia coli of a rat hepatoma cell cDNA coding for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Authors:  K M Crepin; M I Darville; A Michel; L Hue; G G Rousseau
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857

6.  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from frog skeletal muscle: purification, kinetics and immunological properties.

Authors:  M Pyko; M H Rider; L Hue; G Wegener
Journal:  J Comp Physiol B       Date:  1993       Impact factor: 2.200

7.  Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats.

Authors:  J D Sparks; R Zolfaghari; C E Sparks; H C Smith; E A Fisher
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808

8.  Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA.

Authors:  M Miralpeix; E Carballo; R Bartrons; K Crepin; L Hue; G G Rousseau
Journal:  Diabetologia       Date:  1992-03       Impact factor: 10.122

9.  The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling.

Authors:  Sascha Bulik; Hermann-Georg Holzhütter; Nikolaus Berndt
Journal:  BMC Biol       Date:  2016-03-02       Impact factor: 7.431
  9 in total

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