G Pichler1, N Amigo2, M Tellez-Plaza3, M A Pardo-Cea4, A Dominguez-Lucas5, V G Marrachelli6, D Monleon6, J C Martin-Escudero7, J F Ascaso8, F J Chaves9, R Carmena8, J Redon10. 1. Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain. 2. Biosfer Teslab, Reus, Spain; Metabolomics platform, Rovira i Virgili University, Tarragona, Spain; Intitut d'Investigació Sanitària Pere i Virgili (IISPV), Reus, Spain. 3. Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Departments of Environmental Health Sciences, Medicine, and Epidemiology, Johns Hopkins Medical Institutions, Baltimore, USA. 4. Biosfer Teslab, Reus, Spain. 5. Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain. 6. Metabolomic and Molecular Image Lab, Biomedical Research Institute INCLIVA, Valencia, Spain. 7. Department of Internal Medicine, University Hospital Rio Hortega, Valladolid, Spain. 8. Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain. 9. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain. 10. Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER 03/06 Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, Spain. Electronic address: josep.redon@uv.es.
Abstract
BACKGROUND: The association of low-density lipoprotein (LDL) particle composition with cardiovascular risk has not been explored before. The aim was to evaluate the relationship between baseline LDL particle size and composition (proportions of large, medium and small LDL particles over their sum expressed as small-LDL %, medium-LDL % and large-LDL %) and incident cardiovascular disease in a population-based study. METHODS: Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale®). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale® technique in a representative sample of 1162 adult men and women from Spain. RESULTS: The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 ± 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively. CONCLUSIONS: Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD.
BACKGROUND: The association of low-density lipoprotein (LDL) particle composition with cardiovascular risk has not been explored before. The aim was to evaluate the relationship between baseline LDL particle size and composition (proportions of large, medium and small LDL particles over their sum expressed as small-LDL %, medium-LDL % and large-LDL %) and incident cardiovascular disease in a population-based study. METHODS: Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale®). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale® technique in a representative sample of 1162 adult men and women from Spain. RESULTS: The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 ± 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively. CONCLUSIONS: Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD.
Authors: Francisco Algaba-Chueca; Elsa Maymó-Masip; Mónica Ballesteros; Albert Guarque; Alejandro Majali-Martínez; Olga Freixes; Núria Amigó; Sonia Fernández-Veledo; Joan Vendrell; Ana Megía Journal: Biomedicines Date: 2022-04-29
Authors: Erica Behling-Kelly; Carol E Haak; Patrick Carney; Jessica Waffle; Kelly Eaton; Robert Goggs Journal: J Vet Intern Med Date: 2022-04-14 Impact factor: 3.175
Authors: N R W Geiker; C Mølgaard; S Iuliano; R Rizzoli; Y Manios; L J C van Loon; J-M Lecerf; G Moschonis; J-Y Reginster; I Givens; A Astrup Journal: Osteoporos Int Date: 2019-11-14 Impact factor: 4.507
Authors: Maria Tellez-Plaza; Mercedes Sotos-Prieto; Mario Delgado-Velandia; Vannina Gonzalez-Marrachelli; Arce Domingo-Relloso; Marta Galvez-Fernandez; Maria Grau-Perez; Pablo Olmedo; Iñaki Galan; Fernando Rodriguez-Artalejo; Nuria Amigo; Laisa Briongos-Figuero; Josep Redon; Juan Carlos Martin-Escudero; Daniel Monleon-Salvado Journal: Int J Behav Nutr Phys Act Date: 2022-01-27 Impact factor: 6.457