Literature DB >> 29627729

Biomedical analysis of formalin-fixed, paraffin-embedded tissue samples: The Holy Grail for molecular diagnostics.

Boglarka Donczo1, Andras Guttman2.   

Abstract

More than a century ago in 1893, a revolutionary idea about fixing biological tissue specimens was introduced by Ferdinand Blum, a German physician. Since then, a plethora of fixation methods have been investigated and used. Formalin fixation with paraffin embedment became the most widely used types of fixation and preservation method, due to its proper architectural conservation of tissue structures and cellular shape. The huge collection of formalin-fixed, paraffin-embedded (FFPE) sample archives worldwide holds a large amount of unearthed information about diseases that could be the Holy Grail in contemporary biomarker research utilizing analytical omics based molecular diagnostics. The aim of this review is to critically evaluate the omics options for FFPE tissue sample analysis in the molecular diagnostics field.
Copyright © 2018. Published by Elsevier B.V.

Entities:  

Keywords:  FFPE; Genomics; Glycomics; Metabolomics; Molecular diagnostics; Proteomics

Mesh：

Substances：

Year:  2018        PMID： 29627729     DOI： 10.1016/j.jpba.2018.03.065

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  12 in total

1.  The effect of sample age on the metabolic information extracted from formalin-fixed and paraffin embedded tissue samples using desorption electrospray ionization mass spectrometry imaging.

Authors:  Olof Gerdur Isberg; Yuchen Xiang; Sigridur Klara Bodvarsdottir; Jon Gunnlaugur Jonasson; Margret Thorsteinsdottir; Zoltan Takats
Journal:  J Mass Spectrom Adv Clin Lab       Date:  2021-10-28

2.  Practical tips to using formalin-fixed paraffin-embedded tissue archives for molecular diagnostics in a South African setting.

Authors:  Barbara S van Deventer; Lorraine du Toit-Prinsloo; Chantal van Niekerk
Journal:  Afr J Lab Med       Date:  2022-06-23

3.  Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon.

Authors:  Aapo Ristaniemi; Dristi Regmi; Diponkor Mondal; Jari Torniainen; Petri Tanska; Lauri Stenroth; Mikko A J Finnilä; Juha Töyräs; Rami K Korhonen
Journal:  J R Soc Interface       Date:  2021-01-27       Impact factor: 4.118

4.  DNA extraction from FFPE tissue samples - a comparison of three procedures.

Authors:  Agnieszka K Sarnecka; Dominika Nawrat; Monika Piwowar; Janusz Ligęza; Jakub Swadźba; Piotr Wójcik
Journal:  Contemp Oncol (Pozn)       Date:  2019-03-26

Review 5.  New diagnostic molecular markers and biomarkers in odontogenic tumors.

Authors:  Alieh Farshbaf; Reza Zare; Farnaz Mohajertehran; Nooshin Mohtasham
Journal:  Mol Biol Rep       Date:  2021-04-06       Impact factor: 2.316

6.  Nested PCR for the Diagnosis of Feline Sporotrichosis From Formalin-Fixed and Paraffin-Embedded Samples Using Different DNA Extraction Protocols.

Authors:  Raul Leal Faria Luiz; Rodrigo Caldas Menezes; Sandro Antonio Pereira; Raquel de Vasconcellos Carvalhaes de Oliveira; Manoel Marques Evangelista Oliveira
Journal:  Front Vet Sci       Date:  2022-01-05

Review 7.  The molecular mechanisms of inflammation and scarring in the kidneys of immunoglobulin A nephropathy : Gene involvement in the mechanisms of inflammation and scarring in kidney biopsy of IgAN patients.

Authors:  Francesco Paolo Schena; Michele Rossini; Daniela Isabel Abbrescia; Gianluigi Zaza
Journal:  Semin Immunopathol       Date:  2021-10-21       Impact factor: 9.623

8.  Targeted transcriptomic analyses of RNA isolated from formalin-fixed and paraffin-embedded human menisci.

Authors:  Farrah A Monibi; Tania Pannellini; Brett Croen; Miguel Otero; Russell Warren; Scott A Rodeo
Journal:  J Orthop Res       Date:  2021-08-18       Impact factor: 3.102

9.  Formalin-fixed paraffin-embedded renal biopsy tissues: an underexploited biospecimen resource for gene expression profiling in IgA nephropathy.

Authors:  Sharon Natasha Cox; Samantha Chiurlia; Chiara Divella; Michele Rossini; Grazia Serino; Mario Bonomini; Vittorio Sirolli; Francesca B Aiello; Gianluigi Zaza; Isabella Squarzoni; Concetta Gangemi; Maria Stangou; Aikaterini Papagianni; Mark Haas; Francesco Paolo Schena
Journal:  Sci Rep       Date:  2020-09-16       Impact factor: 4.379

10.  Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study.

Authors:  Victor Coutinho Bastos; Jéssica Gardone Vitório; Roberta Rayra Martins-Chaves; Flávia Leite-Lima; Yuri Abner Rocha Lebron; Victor Rezende Moreira; Filipe Fideles Duarte-Andrade; Thaís Dos Santos Fontes Pereira; Lucilaine Valéria de Souza Santos; Liséte Celina Lange; Adriana Nori de Macedo; Gisele André Baptista Canuto; Carolina Cavaliéri Gomes; Ricardo Santiago Gomez
Journal:  Front Oral Health       Date:  2021-06-18
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