Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Altered Cellular Metabolism Drives Trained Immunity.

Literature DB >> 29627292

Altered Cellular Metabolism Drives Trained Immunity.

Yahya Sohrabi¹, Rinesh Godfrey², Hannes M Findeisen³.

Abstract

Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

Keywords: HSPCs; epigenetics; immunometabolism; monocytes/macrophages; trained immunity

Mesh：

Year: 2018 PMID： 29627292 DOI： 10.1016/j.tem.2018.03.012

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

Keyword Cloud
Cited

13 in total

1. Differentiation of circulating monocytes into macrophages with metabolically activated phenotype regulates inflammation in dyslipidemia patients.

Authors: Elena Berenice Martínez-Shio; Ángel Martín Cárdenas-Hernández; Verónica Jiménez-Suárez; Laura Sherell Marín-Jáuregui; Claudia Castillo-Martin Del Campo; Roberto González-Amaro; Carlos D Escobedo-Uribe; Adriana Elizabeth Monsiváis-Urenda
Journal: Clin Exp Immunol Date: 2022-05-13 Impact factor: 4.330

Review 2. The innate immune response to allotransplants: mechanisms and therapeutic potentials.

Authors: Jordi Ochando; Farideh Ordikhani; Peter Boros; Stefan Jordan
Journal: Cell Mol Immunol Date: 2019-02-25 Impact factor: 11.530

3. Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF.

Authors: Jianing Wang; Chunshu Yang; Xiaoyu Hou; Jingyi Xu; Yang Yun; Ling Qin; Pingting Yang
Journal: Front Immunol Date: 2021-05-12 Impact factor: 7.561

4. Differentiation of circulating monocytes into macrophages with metabolically activated phenotype regulates inflammation in dyslipidemia patients.

5. Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes.

Authors: Katharina Bomans; Judith Schenz; Isabella Sztwiertnia; Dominik Schaack; Markus Alexander Weigand; Florian Uhle
Journal: Front Immunol Date: 2018-11-19 Impact factor: 7.561

Review 6. Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes.

Authors: Eleftheria Ieronymaki; Maria G Daskalaki; Konstantina Lyroni; Christos Tsatsanis
Journal: Front Immunol Date: 2019-06-12 Impact factor: 7.561

7. mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes.

Authors: Yahya Sohrabi; Sina M M Lagache; Lucia Schnack; Rinesh Godfrey; Florian Kahles; Dennis Bruemmer; Johannes Waltenberger; Hannes M Findeisen
Journal: Front Immunol Date: 2019-01-22 Impact factor: 7.561

Review 8. Trained Immunity and Reactivity of Macrophages and Endothelial Cells.

Authors: Charles Drummer; Fatma Saaoud; Ying Shao (邵颖); Yu Sun (孙宇); Keman Xu (徐克曼); Yifan Lu (路一凡); Dong Ni (倪栋); Diana Atar; Xiaohua Jiang (蒋晓华); Hong Wang (王虹); Xiaofeng Yang
Journal: Arterioscler Thromb Vasc Biol Date: 2020-12-31 Impact factor: 8.311

9. miR-9-5p regulates immunometabolic and epigenetic pathways in β-glucan-trained immunity via IDH3α.

Authors: Haibo Su; Zhongping Liang; ShuFeng Weng; Chaonan Sun; Jiaxin Huang; TianRan Zhang; Xialian Wang; Shanshan Wu; Zhi Zhang; Yiqi Zhang; Qing Gong; Ying Xu
Journal: JCI Insight Date: 2021-05-10

10. LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes.

Authors: Yahya Sohrabi; Glenn V H Sonntag; Laura C Braun; Sina M M Lagache; Marie Liebmann; Luisa Klotz; Rinesh Godfrey; Florian Kahles; Johannes Waltenberger; Hannes M Findeisen
Journal: Front Immunol Date: 2020-03-10 Impact factor: 7.561