BACKGROUND: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. METHODS: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). RESULTS: Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01). CONCLUSION: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.
BACKGROUND: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. METHODS: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). RESULTS: Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01). CONCLUSION: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.
Authors: Raji R Nair; Joshua Hsu; Justin T Jacob; Christopher M Pineda; Ryan P Hobbs; Pierre A Coulombe Journal: Proc Natl Acad Sci U S A Date: 2021-03-30 Impact factor: 11.205
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Authors: Pavel Dundr; Barbora Bazalová; Michaela Bártů; Tjalling Bosse; Jana Drozenová; Pavel Fabian; Oluwole Fadare; Jitka Hausnerová; Radek Jakša; Jan Laco; Sigurd F Lax; Radoslav Matěj; W Glenn McCluggage; Gábor Méhes; Romana Michálková; Kristýna Němejcová; Naveena Singh; Simona Stolnicu; Petr Škapa; Marián Švajdler; Ivana Stružinská Journal: Virchows Arch Date: 2022-05-13 Impact factor: 4.535
Authors: Lucia Roa-Peña; Cindy V Leiton; Sruthi Babu; Chun-Hao Pan; Elizabeth A Vanner; Ali Akalin; Jela Bandovic; Richard A Moffitt; Kenneth R Shroyer; Luisa F Escobar-Hoyos Journal: Sci Rep Date: 2019-08-02 Impact factor: 4.379