Matej Skorvanek1, Pablo Martinez-Martin2, Norbert Kovacs3, Ivan Zezula4, Mayela Rodriguez-Violante5, Jean-Christophe Corvol6, Pille Taba7, Klaus Seppi8, Oleg Levin9, Anette Schrag10, Iciar Aviles-Olmos11, Mario Alvarez-Sanchez12, Tomoko Arakaki13, Zsuzsanna Aschermann14, Eve Benchetrit6, Charline Benoit6, Alberto Bergareche-Yarza15, Amin Cervantes-Arriaga16, Anabel Chade17, Florence Cormier6, Veronika Datieva9, David A Gallagher18, Nelida Garretto13, Zuzana Gdovinova19, Oscar Gershanik17, Milan Grofik20, Vladimir Han19, Liis Kadastik-Eerme7, Monica M Kurtis21, Graziella Mangone6, Juan Carlos Martinez-Castrillo22, Amelia Mendoza-Rodriguez23, Michal Minar24, Henry P Moore25, Mari Muldmaa26, Christoph Mueller8, Bernadette Pinter8, Werner Poewe8, Karin Rallmann7, Eva Reiter8, Carmen Rodriguez-Blazquez2, Carlos Singer25, Peter Valkovic24, Christopher G Goetz27, Glenn T Stebbins27. 1. Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Dept. of Neurology, University Hospital L. Pasteur, Kosice, Slovak Republic; Centre of Experimental, Translational and Clinical Medicine, Technology and Innovation Park, P. J. Safarik University, Kosice, Slovak Republic. Electronic address: mskorvanek@gmail.com. 2. National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain. 3. Dept. of Neurology, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary. 4. Inst. of Mathematics, P. J. Safarik University, Kosice, Slovak Republic. 5. Movement Disorders Unit, Instituto Nacional de Neurologia y Neurocirugia, Mexico DF, Mexico. 6. Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France. 7. Dept. of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia. 8. Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria. 9. Dept. of Neurology, Russian Medical Academy of Postgraduate Education, Moscow, Russia. 10. Dept. of Clinical Neuroscience, UCL Institute of Neurology, London, UK. 11. Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK. 12. Dept. of Movement Disorders and Neurodegeneration, CIREN, La Habana, Cuba. 13. Dept. of Neurology, Hospital Ramos Mejia, Buenos Aires, Argentina. 14. Dept. of Neurology, University of Pécs, Pécs, Hungary. 15. Dept. of Neurology, Donostia Hospital, Biodonostia Institute and CIBERNED, Sen Sebastian, Spain. 16. Clinical Neurodegenerative Diseases Research Unit, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico. 17. Movement Disorders Unit, Institute of Neurosciences, Favaloro University, INECO, Buenos Aires, Argentina. 18. Barts Health NHS Trust, The Royal London Hospital, London, UK. 19. Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Dept. of Neurology, University Hospital L. Pasteur, Kosice, Slovak Republic. 20. Dept. of Neurology, Comenius University, Martin, Slovak Republic. 21. Movement Disorders Program, Dept. of Neurology, Hospital Ruber Internacional, Madrid, Spain. 22. Movement Disorders Unit, Dept. of Neurology, Hospital Ramon y Cajal, IRYCIS, Madrid, Spain. 23. Department of Neurology, Complejo Asistencial de Segovia, Segovia, Spain. 24. 2nd Dept. of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic. 25. Dept. of Neurology, University of Miami, Miami, FL, USA. 26. Dept. of Neurology, North Estonian Medical Center, Tallinn, Estonia. 27. Dept. of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Abstract
BACKGROUND: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. METHODS: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. RESULTS: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. CONCLUSIONS: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.
BACKGROUND: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PDpatients. METHODS: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. RESULTS: A total of 3206 PDpatients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. CONCLUSIONS: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.