Giuseppe Granata1, Riccardo Di Iorio2, Roberto Romanello2, Francesco Iodice2, Stanisa Raspopovic3, Francesco Petrini3, Ivo Strauss4, Giacomo Valle4, Thomas Stieglitz5, Paul Čvančara5, David Andreu6, Jean-Louis Divoux7, David Guiraud6, Loic Wauters7, Arthur Hiairrassary6, Winnie Jensen8, Silvestro Micera9, Paolo Maria Rossini10. 1. Institute of Neurology, Catholic University of The Sacred Heart, Roma, Italy. Electronic address: granata.gius@gmail.com. 2. Institute of Neurology, Catholic University of The Sacred Heart, Roma, Italy. 3. Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. 4. The Biorobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy. 5. Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg D-79110, Germany. 6. INRIA Camin Team, University of Montpellier, France. 7. AXONIC/Groupe MXM, France. 8. Aalborg University, Center for Sensory-Motor Interaction, Dept. Health Science and Technology, Denmark. 9. Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; The Biorobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy. 10. Institute of Neurology, Catholic University of The Sacred Heart, Roma, Italy; Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Roma, Italy.
Abstract
OBJECTIVE: The aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording "phantom" somatosensory evoked potentials from the corresponding brain areas. METHODS: We implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees. Two channels of the implants that were able to elicit sensations during intraneural nerve stimulation were chosen, in both patients, for recording somatosensory evoked potentials. RESULTS: We recorded reproducible evoked responses by stimulating the median and the ulnar nerves in both cases. Latencies were in accordance with the arrival of somatosensory information to the primary somatosensory cortex. CONCLUSION: Our results provide evidence that sensations generated by intraneural stimulation are truly perceived by amputees and located in the phantom hand. Moreover, our results strongly suggest that sensations perceived in different parts of the phantom hand result in different evoked responses. SIGNIFICANCE: Somatosensory evoked potentials obtained by selective intraneural electrical stimulation in amputee patients are a useful tool to provide an objective demonstration of somatosensory feedback in new generation bidirectional prostheses.
OBJECTIVE: The aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording "phantom" somatosensory evoked potentials from the corresponding brain areas. METHODS: We implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees. Two channels of the implants that were able to elicit sensations during intraneural nerve stimulation were chosen, in both patients, for recording somatosensory evoked potentials. RESULTS: We recorded reproducible evoked responses by stimulating the median and the ulnar nerves in both cases. Latencies were in accordance with the arrival of somatosensory information to the primary somatosensory cortex. CONCLUSION: Our results provide evidence that sensations generated by intraneural stimulation are truly perceived by amputees and located in the phantom hand. Moreover, our results strongly suggest that sensations perceived in different parts of the phantom hand result in different evoked responses. SIGNIFICANCE: Somatosensory evoked potentials obtained by selective intraneural electrical stimulation in amputee patients are a useful tool to provide an objective demonstration of somatosensory feedback in new generation bidirectional prostheses.
Authors: G Valle; F M Petrini; I Strauss; F Iberite; E D'Anna; G Granata; M Controzzi; C Cipriani; T Stieglitz; P M Rossini; A Mazzoni; S Raspopovic; S Micera Journal: Sci Rep Date: 2018-11-12 Impact factor: 4.379
Authors: I Strauss; G Valle; F Artoni; E D'Anna; G Granata; R Di Iorio; D Guiraud; T Stieglitz; P M Rossini; S Raspopovic; F M Petrini; S Micera Journal: Sci Rep Date: 2019-12-17 Impact factor: 4.379
Authors: Manzhao Hao; Chih-Hong Chou; Jie Zhang; Fei Yang; Chunyan Cao; Pengyu Yin; Wenyuan Liang; Chuanxin M Niu; Ning Lan Journal: IEEE Open J Eng Med Biol Date: 2020-03-19
Authors: Federico Ranieri; Giovanni Pellegrino; Anna Lisa Ciancio; Gabriella Musumeci; Emiliano Noce; Angelo Insola; Lorenzo Alirio Diaz Balzani; Vincenzo Di Lazzaro; Giovanni Di Pino Journal: J Physiol Date: 2022-01-12 Impact factor: 6.228
Authors: Giacomo Valle; Francesco Iberite; Ivo Strauss; Edoardo D'Anna; Giuseppe Granata; Riccardo Di Iorio; Thomas Stieglitz; Stanisa Raspopovic; Francesco M Petrini; Paolo M Rossini; Silvestro Micera Journal: Front Med Technol Date: 2021-03-09