Literature DB >> 29625037

A Much-Needed Boost for the Dwindling Antibiotic Pipeline.

Scott C Blanchard1.   

Abstract

In this issue of Molecular Cell, Pantel et al. (2018) identify and synthetically optimize a novel ribosome-targeting antimicrobial from a potentially rich new source of bioactive natural products.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29625037      PMCID： PMC6296369          DOI： 10.1016/j.molcel.2018.03.023

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  6 in total

1.  Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Authors:  Nelson B Olivier; Roger B Altman; Jonas Noeske; Gregory S Basarab; Erin Code; Andrew D Ferguson; Ning Gao; Jian Huang; Manuel F Juette; Stephania Livchak; Matthew D Miller; D Bryan Prince; Jamie H D Cate; Ed T Buurman; Scott C Blanchard
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-03       Impact factor: 11.205

2.  Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.

Authors:  Lucile Pantel; Tanja Florin; Malgorzata Dobosz-Bartoszek; Emilie Racine; Matthieu Sarciaux; Marine Serri; Jessica Houard; Jean-Marc Campagne; Renata Marcia de Figueiredo; Camille Midrier; Sophie Gaudriault; Alain Givaudan; Anne Lanois; Steve Forst; André Aumelas; Christelle Cotteaux-Lautard; Jean-Michel Bolla; Carina Vingsbo Lundberg; Douglas L Huseby; Diarmaid Hughes; Philippe Villain-Guillot; Alexander S Mankin; Yury S Polikanov; Maxime Gualtieri
Journal:  Mol Cell       Date:  2018-04-05       Impact factor: 17.970

Review 3.  The antibiotic resistance crisis, with a focus on the United States.

Authors:  Evan Martens; Arnold L Demain
Journal:  J Antibiot (Tokyo)       Date:  2017-03-01       Impact factor: 2.649

Review 4.  The antibiotic pipeline: reviving research and development and speeding drugs to market.

Authors:  Katherine H Luepke; John F Mohr
Journal:  Expert Rev Anti Infect Ther       Date:  2017-03-29       Impact factor: 5.091

5.  Miscoding-induced stalling of substrate translocation on the bacterial ribosome.

Authors:  Jose L Alejo; Scott C Blanchard
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-25       Impact factor: 11.205

6.  Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Authors:  Alexis I Cocozaki; Roger B Altman; Jian Huang; Ed T Buurman; Steven L Kazmirski; Peter Doig; D Bryan Prince; Scott C Blanchard; Jamie H D Cate; Andrew D Ferguson
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-05       Impact factor: 11.205
  6 in total
  1 in total

1.  The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific.

Authors:  Anne Lanois-Nouri; Lucile Pantel; Jun Fu; Jessica Houard; Jean-Claude Ogier; Yury S Polikanov; Emilie Racine; Hailong Wang; Sophie Gaudriault; Alain Givaudan; Maxime Gualtieri
Journal:  mBio       Date:  2022-01-11       Impact factor: 7.867
  1 in total

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