| Literature DB >> 29624456 |
Guoqing Zhang1,2,3, Fanyue Meng1,2, Zhen Guo2,4, Tao Guo2, Hui Peng5, Jian Xiao5, Botao Liu2, Vikaramjeet Singh2, Shuangying Gui1, Peter York4, Wei Qian5, Li Wu2,3, Jiwen Zhang1,2,3.
Abstract
γ-Cyclodextrin metal-organic frameworks (γ-CD-MOFs) are highly porous and bio-friendly novel materials formed by γ-CD as an organic ligand and potassium ion as an inorganic metal centre. The aim of this study was to enhance the stability of vitamin A palmitate (VAP) using γ-CD-MOFs as the carrier. Herein, γ-CD-MOFs displayed VAP microencapsulating capacity of 9.77 ± 0.24% with molar ratio as nMOFs:nVAP = 3.2:1.0. It was important to find that the improved stability of VAP microencapsulated by γ-CD-MOFs without addition of any antioxidant(s) was better than that of the best available reference product in the market, with 1.6-fold elongated half-life. The protecting mechanism of γ-CD-MOFs for VAP contributed that VAP molecules preferentially curled inside the cavities of dual γ-CD pairs in γ-CD-MOFs. It was proved that γ-CD-MOFs were an efficient new carrier to deliver and protect VAP for food and pharmaceutical applications.Entities:
Keywords: microencapsulation; stability; vitamin A; γ-Cyclodextrin metal-organic frameworks
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Year: 2018 PMID： 29624456 DOI： 10.1080/02652048.2018.1462417
Source DB: PubMed Journal: J Microencapsul ISSN： 0265-2048 Impact factor: 3.142