Literature DB >> 29624065

Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF.

Ting Ting Wang1,2, Ying Jie Wei3, Hui Ming Ge1, Rui Hua Jiao1, Ren Xiang Tan1,3.   

Abstract

Acaulin A (1) and its macrolactone ring-opened congener acaulin B (2) were characterized from the culture of Acaulium sp. H-JQSF (an isopod-associated fungus) as architecturally undescribed trimeric macrodiolides, with the former being antiosteoporotic at 0.4 μM in the prednisolone-induced osteoporotic zebrafish. Identification of acaudiolic acid (3) as the monomeric macrodiolide precursor facilitated the proposal of the acaulin biosynthetic pathway.

Entities:  

Year:  2018        PMID： 29624065     DOI： 10.1021/acs.orglett.8b00883

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144.

Authors:  Jing Zhou; Hairong Zhang; Jing Ye; Xingxin Wu; Weiyi Wang; Houwen Lin; Xiaojun Yan; J Enrico H Lazaro; Tingting Wang; C Benjamin Naman; Shan He
Journal:  Mar Drugs       Date:  2021-03-26       Impact factor: 5.118

Review 2.  Fish Models of Induced Osteoporosis.

Authors:  Joana T Rosa; Vincent Laizé; Paulo J Gavaia; M Leonor Cancela
Journal:  Front Cell Dev Biol       Date:  2021-06-10

3.  Heterologous Expression of a VioA Variant Activates Cryptic Compounds in a Marine-Derived Brevibacterium Strain.

Authors:  Xiao Han; Lukuan Hou; Jing Hou; Yongyu Zhang; Huayue Li; Wenli Li
Journal:  Mar Drugs       Date:  2018-06-02       Impact factor: 5.118

Review 4.  Biosynthesis of Fungal Natural Products Involving Two Separate Pathway Crosstalk.

Authors:  Guangzhi Dai; Qiyao Shen; Youming Zhang; Xiaoying Bian
Journal:  J Fungi (Basel)       Date:  2022-03-21
  4 in total

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