Literature DB >> 29620889

Synthetic Approaches to New Drugs Approved During 2016.

Andrew C Flick1, Hong X Ding2, Carolyn A Leverett1, Sarah J Fink3, Christopher J O'Donnell1.   

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 19 new chemical entities that were approved for the first time in 2016.

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Year:  2018        PMID： 29620889     DOI： 10.1021/acs.jmedchem.8b00260

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Successive Nucleophilic and Electrophilic Allylation for the Catalytic Enantioselective Synthesis of 2,4-Disubstituted Pyrrolidines.

Authors:  Guoshun Luo; Ming Xiang; Michael J Krische
Journal:  Org Lett       Date:  2019-02-28       Impact factor: 6.005

Review 2.  A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds.

Authors:  Tejas M Dhameliya; Hiren A Donga; Punit V Vaghela; Bhoomi G Panchal; Dipen K Sureja; Kunjan B Bodiwala; Mahesh T Chhabria
Journal:  RSC Adv       Date:  2020-09-03       Impact factor: 4.036

3.  Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines.

Authors:  Jesus Rodrigalvarez; Luke A Reeve; Javier Miró; Matthew J Gaunt
Journal:  J Am Chem Soc       Date:  2022-02-25       Impact factor: 16.383

Review 4.  Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism.

Authors:  Mohammed A S Abourehab; Alaa M Alqahtani; Bahaa G M Youssif; Ahmed M Gouda
Journal:  Molecules       Date:  2021-11-04       Impact factor: 4.411

5.  4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent.

Authors:  Shoji Kobayashi; Tomoki Tamura; Saki Yoshimoto; Takashi Kawakami; Araki Masuyama
Journal:  Chem Asian J       Date:  2019-10-16
  5 in total

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