Thomas Hegyi1, Alan Kleinfeld2, Andrew Huber2, Barry Weinberger3, Naureen Memon4, Weichung Joe Shih5, Mary Carayannopoulos6, William Oh7. 1. a Department of Pediatrics , Robert Wood Johnson Medical School, Rutgers, State University of New Jersey , New Brunswick , NJ , USA. 2. b Fluoresprobe Sciences , San Diego , CA , USA. 3. c Department of Pediatrics , Cohen Children's Medical Center, Northwell Health , New Hyde Park , NY , USA. 4. d MidAtlantic Neonatology Ass. Goryeb Children's Hospital , Morristown , NJ , USA. 5. e Rutgers School of Public Health , Rutgers University , New Brunswick , NJ , USA. 6. f Department of Pathology and Laboratory Medicine , Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey , New Brunswick , NJ , USA. 7. g Department of Pediatrics , Alpert Medical School of Brown University , Providence , RI , USA.
Abstract
Objective: To determine the plasma triglyceride (TG) and unbound free fatty acid (FFAu) levels in infants treated with increasing dosages of soybean lipid, intralipid (IL), infusion. Study design: TG and FFAu levels were measured in 78 preterm infants (BW 500-2000 g; GA 23-34 weeks) using the fluorescent probe ADIFAB2 and enzymatic method. Results: The infants' BW was 1266.2 ± 440.7 g and GA 28.8 ± 3.1 weeks. TG levels were 77.4 ± 50 mg/dL, 140.2 ± 188 mg/dL (p < .04 compared to levels during low dose IL infusion) and 135.6 ± 118 mg/dL (p < .004), respectively during increased IL rates. FFAu levels were 17.7 ± 13 nM, 47.3 ± 102.8 nM (p = .07) and 98 ± 234 nM (p = .03). TG levels correlated with IL dose, the rate of IL administration, and FFAu levels. TG and FFAu levels were higher in infants below 28 weeks' gestation Conclusions: Increasing dosage of IL is associated with increasing levels of TG and FFAu, especially in infants below 29 weeks of gestation. The increased level of FFAu suggests inefficient cellular utilization.
Objective: To determine the plasma triglyceride (TG) and unbound free fatty acid (FFAu) levels in infants treated with increasing dosages of soybeanlipid, intralipid (IL), infusion. Study design: TG and FFAu levels were measured in 78 preterm infants (BW 500-2000 g; GA 23-34 weeks) using the fluorescent probe ADIFAB2 and enzymatic method. Results: The infants' BW was 1266.2 ± 440.7 g and GA 28.8 ± 3.1 weeks. TG levels were 77.4 ± 50 mg/dL, 140.2 ± 188 mg/dL (p < .04 compared to levels during low dose IL infusion) and 135.6 ± 118 mg/dL (p < .004), respectively during increased IL rates. FFAu levels were 17.7 ± 13 nM, 47.3 ± 102.8 nM (p = .07) and 98 ± 234 nM (p = .03). TG levels correlated with IL dose, the rate of IL administration, and FFAu levels. TG and FFAu levels were higher in infants below 28 weeks' gestation Conclusions: Increasing dosage of IL is associated with increasing levels of TG and FFAu, especially in infants below 29 weeks of gestation. The increased level of FFAu suggests inefficient cellular utilization.
Authors: Andrew H Huber; Baolong Zhu; Thomas Kwan; J Patrick Kampf; Thomas Hegyi; Alan M Kleinfeld Journal: Clin Chem Date: 2012-03-06 Impact factor: 8.327
Authors: Jose Mari S Yuvienco; Ma Emily C Dizon; Alan Kleinfeld; Mujahid Anwar; Mark Hiatt; Thomas Hegyi Journal: Am J Perinatol Date: 2005-11 Impact factor: 1.862
Authors: J Peterson; B E Bihain; G Bengtsson-Olivecrona; R J Deckelbaum; Y A Carpentier; T Olivecrona Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205