Literature DB >> 29618060

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions.

Marit Sletmoen1, Thomas A Gerken2, Bjørn T Stokke3, Joy Burchell4, C Fred Brewer5.   

Abstract

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29618060      PMCID： PMC6001880          DOI： 10.1093/glycob/cwy032

Source DB:  PubMed          Journal:  Glycobiology        ISSN： 0959-6658            Impact factor:   4.313


  42 in total

1.  Dynamic force spectroscopy of single DNA molecules.

Authors:  T Strunz; K Oroszlan; R Schäfer; H J Güntherodt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

Review 2.  Many Light Touches Convey the Message.

Authors:  James W Dennis
Journal:  Trends Biochem Sci       Date:  2015-10-01       Impact factor: 13.807

3.  The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase.

Authors:  Rajindra P Aryal; Tongzhong Ju; Richard D Cummings
Journal:  J Biol Chem       Date:  2009-11-18       Impact factor: 5.157

Review 4.  Protein glycosylation in cancer.

Authors:  Sean R Stowell; Tongzhong Ju; Richard D Cummings
Journal:  Annu Rev Pathol       Date:  2015       Impact factor: 23.472

Review 5.  Carbohydrate to carbohydrate interaction in development process and cancer progression.

Authors:  Kazuko Handa; Sen-Itiroh Hakomori
Journal:  Glycoconj J       Date:  2012-05-18       Impact factor: 2.916

Review 6.  Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers.

Authors:  Tongzhong Ju; Yingchun Wang; Rajindra P Aryal; Sylvain D Lehoux; Xiaokun Ding; Matthew R Kudelka; Christopher Cutler; Junwei Zeng; Jianmei Wang; Xiaodong Sun; Jamie Heimburg-Molinaro; David F Smith; Richard D Cummings
Journal:  Proteomics Clin Appl       Date:  2013-09-09       Impact factor: 3.494

7.  A red meat-derived glycan promotes inflammation and cancer progression.

Authors:  Annie N Samraj; Oliver M T Pearce; Heinz Läubli; Alyssa N Crittenden; Anne K Bergfeld; Kalyan Banda; Christopher J Gregg; Andrea E Bingman; Patrick Secrest; Sandra L Diaz; Nissi M Varki; Ajit Varki
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-29       Impact factor: 11.205

8.  Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody.

Authors:  Nobuyoshi Hayashi; Hirofumi Chiba; Koji Kuronuma; Shinji Go; Yoshihiro Hasegawa; Motoko Takahashi; Shinsei Gasa; Atsushi Watanabe; Tadashi Hasegawa; Yoshio Kuroki; Jinichi Inokuchi; Hiroki Takahashi
Journal:  Cancer Sci       Date:  2012-10-30       Impact factor: 6.716

9.  Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions.

Authors:  Kristin E Haugstad; Soosan Hadjialirezaei; Bjørn T Stokke; C Fred Brewer; Thomas A Gerken; Joy Burchell; Gianfranco Picco; Marit Sletmoen
Journal:  Glycobiology       Date:  2016-06-09       Impact factor: 4.313

10.  Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.

Authors:  Hidenori Ozaki; Hideki Matsuzaki; Hidenobu Ando; Hiroyuki Kaji; Hayao Nakanishi; Yuzuru Ikehara; Hisashi Narimatsu
Journal:  Clin Exp Metastasis       Date:  2012-01-08       Impact factor: 5.150
View more
  6 in total

Review 1.  Nucleocytoplasmic O-glycosylation in protists.

Authors:  Christopher M West; Hyun W Kim
Journal:  Curr Opin Struct Biol       Date:  2019-05-22       Impact factor: 6.809

Review 2.  Polypeptide GalNAc-Ts: from redundancy to specificity.

Authors:  Matilde de Las Rivas; Erandi Lira-Navarrete; Thomas A Gerken; Ramon Hurtado-Guerrero
Journal:  Curr Opin Struct Biol       Date:  2019-01-28       Impact factor: 6.809

3.  The influence of ABO blood groups on COVID-19 susceptibility and severity: A molecular hypothesis based on carbohydrate-carbohydrate interactions.

Authors:  José Caetano Silva-Filho; Cynthia Germoglio Farias de Melo; Janaína Lima de Oliveira
Journal:  Med Hypotheses       Date:  2020-08-02       Impact factor: 1.538

4.  Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding.

Authors:  Lisa M Parsons; Kim M Bouwman; Hugo Azurmendi; Robert P de Vries; John F Cipollo; Monique H Verheije
Journal:  J Biol Chem       Date:  2019-03-22       Impact factor: 5.157

5.  Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens.

Authors:  Feng Xu; Dong Wang; JianXiu Cui; Jie Li; Hongchuan Jiang
Journal:  Cancer Manag Res       Date:  2020-02-11       Impact factor: 3.989

6.  Structural basis for peptide substrate specificities of glycosyltransferase GalNAc-T2.

Authors:  Sai Pooja Mahajan; Yashes Srinivasan; Jason W Labonte; Matthew P DeLisa; Jeffrey J Gray
Journal:  ACS Catal       Date:  2021-02-19       Impact factor: 13.084
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.