| Literature DB >> 29616812 |
Gil Soo Kim1,2, Wonmin Ko3, Jong Won Kim1, Min-Hye Jeong4, Sung-Kyun Ko1,2, Jae-Seoun Hur4, Hyuncheol Oh3, Jae-Hyuk Jang1,2, Jong Seog Ahn1,2.
Abstract
Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher's method. Compound 2 inhibited nitric oxide (NO) production with IC50 values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, 2 decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.Entities:
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Year: 2018 PMID： 29616812 DOI： 10.1021/acs.jnatprod.7b01022
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050