Literature DB >> 2961634

The effects of chlorbutol on skeletal muscle sarcoplasmic reticulum function in porcine malignant hyperpyrexia.

A T Sim1, M D White, M A Denborough.   

Abstract

1. Chlorbutol, a muscle relaxant, inhibits the in vitro muscle hypercontractility which is characteristic of the anaesthetic complication, malignant hyperpyrexia (MH). 2. Studies on isolated sarcoplasmic reticulum vesicles have shown that this effect of chlorbutol in MH is not due to a modification of Ca2+-transport mechanisms.

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Year:  1987        PMID: 2961634     DOI: 10.1016/0020-711x(87)90241-2

Source DB:  PubMed          Journal:  Int J Biochem        ISSN: 0020-711X


  1 in total

1.  Dual effects of chlorobutanol on secretory response and intracellular Ca2+ dynamics in isolated pancreatic acini of the rat.

Authors:  Y Habara; T Kanno
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

  1 in total

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