Clara Tammy Kim1, Woojae Myung2, Matthew Lewis3, Hyewon Lee2,4, Satbyul Estella Kim5, Kyungsang Lee6, Chunsoo Lee6, Junbae Choi6, Ho Kim4, Bernard J Carroll7, Doh Kwan Kim6. 1. Institute of Life and Death Studies, Hallym University, Chuncheon, Gangwon-do, Republic of Korea. 2. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. 3. Aged Psychiatry Service, Caulfield Hospital, Alfred Health, VIC, Australia. 4. Institute of Health and Environment, Seoul National University & Department of Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea. 5. Center for Social and Environmental System Research, National Institute for Environmental Studies, Tsukuba, Japan. 6. Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea. 7. Department of Psychiatry, Emeritus, Duke University Medical Center, Durham, NC, USA.
Abstract
BACKGROUND: There is a growing concern that general anesthesia could increase the risk of dementia. However, the relationship between anesthesia and subsequent dementia is still undetermined. OBJECTIVE: To determine whether the risk of dementia increases after exposure to general anesthesia. METHODS: A population-based prospective cohort study analyzing the Korean National Health Insurance Service-National Sample Cohort database was conducted of all persons aged over 50 years (n = 219,423) from 1 January 2003 and 31 December 2013. RESULTS: 44,956 in the general anesthesia group and 174,469 in the control group were followed for 12 years. The risk of dementia associated with previous exposure to general anesthesia was increased after adjusting for all covariates such as gender, age, health care visit frequency, and co-morbidities (Hazard ratio = 1.285, 95% confidence interval = 1.262-1.384, time-varying Cox hazard model). In addition, the number of anesthetic agents administered, the number of exposures to general anesthesia, the cumulative exposure time, and the organ category involved in surgery were associated with risk of dementia. CONCLUSION: In light of the increasing societal burden of dementia, careful surveillance for dementia and prevention guidelines for patients after general anesthesia are needed.
BACKGROUND: There is a growing concern that general anesthesia could increase the risk of dementia. However, the relationship between anesthesia and subsequent dementia is still undetermined. OBJECTIVE: To determine whether the risk of dementia increases after exposure to general anesthesia. METHODS: A population-based prospective cohort study analyzing the Korean National Health Insurance Service-National Sample Cohort database was conducted of all persons aged over 50 years (n = 219,423) from 1 January 2003 and 31 December 2013. RESULTS: 44,956 in the general anesthesia group and 174,469 in the control group were followed for 12 years. The risk of dementia associated with previous exposure to general anesthesia was increased after adjusting for all covariates such as gender, age, health care visit frequency, and co-morbidities (Hazard ratio = 1.285, 95% confidence interval = 1.262-1.384, time-varying Cox hazard model). In addition, the number of anesthetic agents administered, the number of exposures to general anesthesia, the cumulative exposure time, and the organ category involved in surgery were associated with risk of dementia. CONCLUSION: In light of the increasing societal burden of dementia, careful surveillance for dementia and prevention guidelines for patients after general anesthesia are needed.
Authors: John David Eun; Heidy Jimenez; Leslie Adrien; Adam Wolin; Philippe Marambaud; Peter Davies; Jeremy L Koppel Journal: Mol Med Date: 2022-07-20 Impact factor: 6.376
Authors: Clive Velkers; Miles Berger; Sudeep S Gill; Roderic Eckenhoff; Heather Stuart; Marlo Whitehead; Peter C Austin; Paula A Rochon; Dallas Seitz Journal: J Am Geriatr Soc Date: 2020-10-06 Impact factor: 5.562