Literature DB >> 29614294

GPCR Signaling: The Interplay of Gαi and β-arrestin.

Hemlata Dwivedi1, Mithu Baidya1, Arun K Shukla2.   

Abstract

Biased agonism at G-protein-coupled receptors is generally conceptualized as the ability of certain stimuli to trigger downstream signaling exclusively through one of two effectors. Recent studies reveal that signaling downstream of the β1 adrenergic receptor and the angiotensin II type 1 receptor induced by biased stimuli actually involves both effectors.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2018        PMID: 29614294     DOI: 10.1016/j.cub.2018.02.027

Source DB:  PubMed          Journal:  Curr Biol        ISSN: 0960-9822            Impact factor:   10.834


  4 in total

1.  Structural basis and mechanism of activation of two different families of G proteins by the same GPCR.

Authors:  Kamela O Alegre; Navid Paknejad; Minfei Su; Jian-Shu Lou; Jianyun Huang; Kelsey D Jordan; Edward T Eng; Joel R Meyerson; Richard K Hite; Xin-Yun Huang
Journal:  Nat Struct Mol Biol       Date:  2021-11-10       Impact factor: 15.369

2.  Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.

Authors:  Shubhi Pandey; Xaria X Li; Ashish Srivastava; Mithu Baidya; Punita Kumari; Hemlata Dwivedi; Madhu Chaturvedi; Eshan Ghosh; Trent M Woodruff; Arun K Shukla
Journal:  J Biol Chem       Date:  2019-04-29       Impact factor: 5.157

3.  Measuring agonist-induced ERK MAP kinase phosphorylation for G-protein-coupled receptors.

Authors:  Punita Kumari; Hemlata Dwivedi; Mithu Baidya; Arun K Shukla
Journal:  Methods Cell Biol       Date:  2018-11-19       Impact factor: 1.441

4.  Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.

Authors:  Shubhi Pandey; Punita Kumari; Mithu Baidya; Ryoji Kise; Yubo Cao; Hemlata Dwivedi-Agnihotri; Ramanuj Banerjee; Xaria X Li; Cedric S Cui; John D Lee; Kouki Kawakami; Jagannath Maharana; Ashutosh Ranjan; Madhu Chaturvedi; Gagan Deep Jhingan; Stéphane A Laporte; Trent M Woodruff; Asuka Inoue; Arun K Shukla
Journal:  Mol Cell       Date:  2021-09-27       Impact factor: 19.328

  4 in total

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