| Literature DB >> 2961329 |
Abstract
Human Insulinlike Growth Factor 2 (IGF-2) can promote cell proliferation via the type 2 receptor in K562 cells, a human erythroleukemia cell line with IGF-2/type 2 receptors and insulin receptors but lacking IGF-1/type 1 receptors. Cells are grown in semi-solid agar in the absence and presence of increasing amounts of insulin, IGF-1 and IGF-2. Two strains of K562 cells have been studied, with different concentrations of insulin and IGF-2 receptors. The effect of IGF-2 is proportional to the IGF-2 receptor concentration.Entities:
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Year: 1987 PMID: 2961329 DOI: 10.1016/0006-291x(87)90948-x
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN: 0006-291X Impact factor: 3.575