Literature DB >> 29611633

Deoxynivalenol as potential modulator of human steroidogenesis.

Kinga Anna Urbanek1, Dominika Ewa Habrowska-Górczyńska1, Karolina Kowalska1, Anna Stańczyk2, Kamila Domińska3, Agnieszka Wanda Piastowska-Ciesielska1.   

Abstract

Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species. Exposure to DON might cause disruptive effects such as reduced weight gain, neuroendocrine changes and immune modulation in animals (rats, dogs, pigs). There is huge concern that similar effects can be observed in humans. DON is a potential regulator of intracellular steroidogenesis. It is also possible that DON will be involved in the regulation of miRNAs connected with steroidogenesis. This review summarizes the latest knowledge about the influence of DON on steroidogenesis and human hormonal balance.
Copyright © 2018 John Wiley & Sons, Ltd.

Entities:  

Keywords:  cancerogenesis; deoxynivalenol; miRNA; mycotoxin; steroidogenesis

Mesh：

Substances：

Year:  2018        PMID： 29611633     DOI： 10.1002/jat.3623

Source DB:  PubMed          Journal:  J Appl Toxicol        ISSN： 0260-437X            Impact factor:   3.446


  10 in total

Review 1.  Nrf2: a main responsive element in cells to mycotoxin-induced toxicity.

Authors:  Marta Justyna Kozieł; Karolina Kowalska; Agnieszka Wanda Piastowska-Ciesielska
Journal:  Arch Toxicol       Date:  2021-02-08       Impact factor: 5.153

2.  Deoxynivalenol Modulates the Viability, ROS Production and Apoptosis in Prostate Cancer Cells.

Authors:  Dominika Ewa Habrowska-Górczyńska; Karolina Kowalska; Kinga Anna Urbanek; Kamila Domińska; Agata Sakowicz; Agnieszka Wanda Piastowska-Ciesielska
Journal:  Toxins (Basel)       Date:  2019-05-11       Impact factor: 4.546

3.  Deoxynivalenol induces apoptosis and autophagy in human prostate epithelial cells via PI3K/Akt signaling pathway.

Authors:  Karolina Kowalska; Marta Justyna Kozieł; Dominika Ewa Habrowska-Górczyńska; Kinga Anna Urbanek; Kamila Domińska; Agnieszka Wanda Piastowska-Ciesielska
Journal:  Arch Toxicol       Date:  2021-10-22       Impact factor: 5.153

4.  In Vitro Analysis of Deoxynivalenol Influence on Steroidogenesis in Prostate.

Authors:  Kinga Anna Urbanek; Karolina Kowalska; Dominika Ewa Habrowska-Górczyńska; Kamila Domińska; Agata Sakowicz; Agnieszka Wanda Piastowska-Ciesielska
Journal:  Toxins (Basel)       Date:  2021-09-26       Impact factor: 4.546

Review 5.  Intestinal Barrier, Claudins and Mycotoxins.

Authors:  Marta Justyna Kozieł; Maksymilian Ziaja; Agnieszka Wanda Piastowska-Ciesielska
Journal:  Toxins (Basel)       Date:  2021-10-26       Impact factor: 4.546

Review 6.  Alimentary Risk of Mycotoxins for Humans and Animals.

Authors:  Jagoda Kępińska-Pacelik; Wioletta Biel
Journal:  Toxins (Basel)       Date:  2021-11-21       Impact factor: 4.546

7.  Chromatin Accessibility and Transcriptomic Alterations in Murine Ovarian Granulosa Cells upon Deoxynivalenol Exposure.

Authors:  Hairui Fan; Zhanshi Ren; Chao Xu; Haifei Wang; Zhengchang Wu; Zia Ur Rehman; Shenglong Wu; Ming-An Sun; Wenbin Bao
Journal:  Cells       Date:  2021-10-20       Impact factor: 6.600

8.  Oral deoxynivalenol toxicity in Harlan Sprague Dawley (Hsd:Sprague Dawley® SD®) rat dams and their offspring.

Authors:  Madelyn C Huang; Johnathan R Furr; Veronica G Robinson; Laura Betz; Keith Shockley; Helen Cunny; Kristine Witt; Suramya Waidyanatha; Dori Germolec
Journal:  Food Chem Toxicol       Date:  2020-12-31       Impact factor: 6.023

9.  The Effect of 42-Day Exposure to a Low Deoxynivalenol Dose on the Immunohistochemical Expression of Intestinal ERs and the Activation of CYP1A1 and GSTP1 Genes in the Large Intestine of Pre-pubertal Gilts.

Authors:  Magdalena Gajęcka; Paweł Brzuzan; Iwona Otrocka-Domagała; Łukasz Zielonka; Sylwia Lisieska-Żołnierczyk; Maciej T Gajęcki
Journal:  Front Vet Sci       Date:  2021-07-19

10.  Melatonin Ameliorates the Toxicity Induced by Deoxynivalenol in Murine Ovary Granulosa Cells by Antioxidative and Anti-Inflammatory Effects.

Authors:  Hairui Fan; Shiqin Wang; Haifei Wang; Mingan Sun; Shenglong Wu; Wenbin Bao
Journal:  Antioxidants (Basel)       Date:  2021-06-29
  10 in total

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