Cecilia N Pisoni1, Sebastián A Muñoz2, María N Tamborenea3, Mercedes García4, Ana Curti5, Ana Cappuccio6, Oscar Rillo7, Patricia M Imamura8, Emilce Schneeberger9, Marcela Ballent10, Mario L Cousseau11, Jorge Velasco Zamora12, Verónica Saurit13, Sergio Toloza14, María C Danielsen15, Verónica I Bellomio16, Cesar Graf17, Sergio Paira18, Javier Cavallasca19, Bernardo Pons Estel20, José L C Moreno21, Mónica Díaz22, Paula Alba23, Marcela Verando24, Guillermo Tate3, Eduardo Mysler3, Judith Sarano25, Emma E Civit26, Fabián Risueño27, Pablo Álvarez Sepúlveda28, María S Larroude6, Marcos F Méndez29, Andrea Conforti30, Débora Sohn31. 1. Immunology and Rheumatology Section, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC), Ciudad Autónoma de, Buenos Aires, Argentina. 2. Hospital General de Agudos Juan A. Fernández, Ciudad Autónoma de Buenos Aires, Argentina. 3. Organización Médica de Investigaciones (OMI), Ciudad Autónoma de Buenos Aires, Argentina. 4. Hospital Interzonal General de Agudos "General José de San Martín", Ciudad Autónoma de Buenos Aires, Argentina, Ciudad de La Plata, Argentina. 5. Hospital de Clínicas "José de San Martín", Ciudad Autónoma de Buenos Aires, Argentina. 6. Hospital Cesar Milstein, Ciudad Autónoma de Buenos Aires, Argentina. 7. Hospital General de Agudos "Dr. Ignacio Pirovano", Ciudad Autónoma de Buenos Aires, Argentina. 8. Hospital Italiano, Ciudad Autónoma de Buenos Aires, Argentina. 9. Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina. 10. Hospital Ramón Santamarina, Tandil, Argentina. 11. Policlínica Privada Paz, Tandil, Argentina. 12. Instituto Médico CER, Ciudad de Quilmes, Argentina. 13. Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina. 14. Hospital Interzonal San Juan Bautista, Fernando del Valle de Catamarca, Argentina. 15. Consultorio de Reumatología, Santiago del Estero, Argentina. 16. Centro Médico Privado de Reumatología, San Miguel de Tucumán, Argentina. 17. Centro Médico Mitre, Ciudad de Paraná, Argentina. 18. Hospital José Maria Cullen, Ciudad de Santa Fé, Argentina. 19. Hospital José Bernardo Iturraspe, Ciudad de San Francisco, Argentina. 20. Sanatorio Parque, Ciudad de Rosario, Argentina. 21. Instituto Médico CER, Ciudad de San Juan, Argentina. 22. Centro Traumatológico Bariloche, Ciudad de San Carlos de Bariloche, Argentina. 23. Hospital de Córdoba, Ciudad de Córdoba, Argentina. 24. Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina. 25. Instituto de Investigaciones Médicas "Dr. Alfredo Lanari", Ciudad Autónoma de Buenos Aires, Argentina. 26. Hospital del Carmen, Ciudad de Godoy Cruz, Argentina. 27. Itemédica, Ciudad de Bahía Blanca, Argentina. 28. Hospital de San Isidro, Ciudad de San Isidro, Argentina. 29. Consultorios Pilar, Ciudad de Puerto Madryn, Argentina. 30. OSEP Mendoza, Ciudad de Mendoza, Argentina. 31. Instituto de Diagnóstico Roche, Ciudad de Escobar, Argentina.
Abstract
OBJECTIVE: To study the prevalence and the associated factors of work disability (WD) in systemic lupus erythematosus (SLE) patients. METHODS: A sample of 419 SLE patients from an observational cross-sectional multicenter study was included. Sociodemographic features, disease characteristics, comorbidities, quality of life, unhealthy behaviors, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not being able to work because of SLE. To identify variables associated with work disability, two different multivariate regression models using a stepwise backward method were performed. RESULTS: Prevalence of WD due to SLE was 24.3%. Eighty-nine percent were female and 51% were Caucasians. Mean disease duration was 8.9 ± 7.2 years, and median System Lupus International Collaborating Clinics/American College of Rheumatology damage index SLICC-SDI was 1.5 (range 0-17). In stepwise multivariate logistic regression, living below the poverty line (odds ratio [OR] = 4.65), less than 12 years of education (OR = 2.84), Mestizo ethnicity (OR = 1.94) and SLICC-SDI (OR = 1.25) were predictors of WD. A second model was performed including patient-derived measures; in this model sedentary lifestyle (OR = 2.69) and lower emotional health domain score of the Lupus Quality of Life (LupusQoL) questionnaire (OR = 1.03) were found to be associated to WD and a higher score in LupusQoL physical health domain (OR = 0.93) was protective. CONCLUSION: The prevalence of WD in Argentinian SLE patients was 24.3%. WD was associated with ethnic (Mestizo), socioeconomic (poverty) and disease-related factors. Patient-related outcomes such us sedentary lifestyle and poor emotional quality of life were also associated with WD.
OBJECTIVE: To study the prevalence and the associated factors of work disability (WD) in systemic lupus erythematosus (SLE) patients. METHODS: A sample of 419 SLEpatients from an observational cross-sectional multicenter study was included. Sociodemographic features, disease characteristics, comorbidities, quality of life, unhealthy behaviors, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not being able to work because of SLE. To identify variables associated with work disability, two different multivariate regression models using a stepwise backward method were performed. RESULTS: Prevalence of WD due to SLE was 24.3%. Eighty-nine percent were female and 51% were Caucasians. Mean disease duration was 8.9 ± 7.2 years, and median System Lupus International Collaborating Clinics/American College of Rheumatology damage index SLICC-SDI was 1.5 (range 0-17). In stepwise multivariate logistic regression, living below the poverty line (odds ratio [OR] = 4.65), less than 12 years of education (OR = 2.84), Mestizo ethnicity (OR = 1.94) and SLICC-SDI (OR = 1.25) were predictors of WD. A second model was performed including patient-derived measures; in this model sedentary lifestyle (OR = 2.69) and lower emotional health domain score of the Lupus Quality of Life (LupusQoL) questionnaire (OR = 1.03) were found to be associated to WD and a higher score in LupusQoL physical health domain (OR = 0.93) was protective. CONCLUSION: The prevalence of WD in Argentinian SLEpatients was 24.3%. WD was associated with ethnic (Mestizo), socioeconomic (poverty) and disease-related factors. Patient-related outcomes such us sedentary lifestyle and poor emotional quality of life were also associated with WD.