Literature DB >> 29611195

In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics.

Gian Matteo Rigolin1, Elena Saccenti1, Emanuele Guardalben1, Maurizio Cavallari1, Luca Formigaro1, Barbara Zagatti2, Andrea Visentin3, Francesca R Mauro4, Enrico Lista1, Cristian Bassi2, Laura Lupini2, Francesca Maria Quaglia1, Antonio Urso1, Maria Antonella Bardi1, Laura Bonaldi5, Eleonora Volta1, Elisa Tammiso1, Caterina Ilari4, Luciana Cafforio4, Aurora Melandri1, Francesco Cavazzini1, Massimo Negrini2, Gianpietro Semenzato3, Livio Trentin3, Robin Foà4, Antonio Cuneo1.   

Abstract

Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics.
© 2018 John Wiley & Sons Ltd.

Entities:  

Keywords:  chronic lymphocytic leukaemia; complex karyotype; gene expression profile; overall survival; time to first treatment

Mesh：

Substances：

Year:  2018        PMID： 29611195     DOI： 10.1111/bjh.15174

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  10 in total

Review 1.  The complex karyotype in hematological malignancies: a comprehensive overview by the Francophone Group of Hematological Cytogenetics (GFCH).

Authors:  F Nguyen-Khac; A Bidet; A Daudignon; M Lafage-Pochitaloff; G Ameye; C Bilhou-Nabéra; E Chapiro; M A Collonge-Rame; W Cuccuini; N Douet-Guilbert; V Eclache; I Luquet; L Michaux; N Nadal; D Penther; B Quilichini; C Terre; C Lefebvre; M-B Troadec; L Véronèse
Journal:  Leukemia       Date:  2022-04-16       Impact factor: 12.883

2.  Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact.

Authors:  Panagiotis Baliakas; Sabine Jeromin; Michalis Iskas; Anna Puiggros; Karla Plevova; Florence Nguyen-Khac; Zadie Davis; Gian Matteo Rigolin; Andrea Visentin; Aliki Xochelli; Julio Delgado; Fanny Baran-Marszak; Evangelia Stalika; Pau Abrisqueta; Kristina Durechova; George Papaioannou; Virginie Eclache; Maria Dimou; Theodoros Iliakis; Rosa Collado; Michael Doubek; M Jose Calasanz; Neus Ruiz-Xiville; Carolina Moreno; Marie Jarosova; Alexander C Leeksma; Panayiotis Panayiotidis; Helena Podgornik; Florence Cymbalista; Achilles Anagnostopoulos; Livio Trentin; Niki Stavroyianni; Fred Davi; Paolo Ghia; Arnon P Kater; Antonio Cuneo; Sarka Pospisilova; Blanca Espinet; Anastasia Athanasiadou; David Oscier; Claudia Haferlach; Kostas Stamatopoulos
Journal:  Blood       Date:  2019-01-02       Impact factor: 22.113

3.  The combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia.

Authors:  Andrea Visentin; Laura Bonaldi; Gian Matteo Rigolin; Francesca Romana Mauro; Annalisa Martines; Federica Frezzato; Silvia Imbergamo; Edoardo Scomazzon; Stefano Pravato; Maria Antonella Bardi; Maurizio Cavallari; Eleonora Volta; Francesco Cavazzini; Maurizio Nanni; Ilaria Del Giudice; Monica Facco; Anna Guarini; Gianpietro Semenzato; Robin Foà; Antonio Cuneo; Livio Trentin
Journal:  Br J Cancer       Date:  2019-06-18       Impact factor: 7.640

4.  Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: a multicenter retrospective study.

Authors:  Yunsuk Choi; Jung-Hee Lee; Chul Won Jung; Jae-Cheol Jo; Jin Seok Kim; Inho Kim; Silvia Park; June-Won Cheong; Sang-Hyuk Park; Sung-Yong Kim; Hong-Ghi Lee
Journal:  Korean J Intern Med       Date:  2020-04-14       Impact factor: 2.884

Review 5.  Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype.

Authors:  Thomas Chatzikonstantinou; Christos Demosthenous; Panagiotis Baliakas
Journal:  Front Oncol       Date:  2021-11-29       Impact factor: 6.244

6.  Optical Genome Mapping: A Promising New Tool to Assess Genomic Complexity in Chronic Lymphocytic Leukemia (CLL).

Authors:  Anna Puiggros; Silvia Ramos-Campoy; Joanna Kamaso; Mireia de la Rosa; Marta Salido; Carme Melero; María Rodríguez-Rivera; Sandrine Bougeon; Rosa Collado; Eva Gimeno; Rocío García-Serra; Sara Alonso; Marco Antonio Moro-García; María Dolores García-Malo; Xavier Calvo; Leonor Arenillas; Ana Ferrer; Tuomo Mantere; Alexander Hoischen; Jacqueline Schoumans; Blanca Espinet
Journal:  Cancers (Basel)       Date:  2022-07-11       Impact factor: 6.575

Review 7.  Biological significance and prognostic/predictive impact of complex karyotype in chronic lymphocytic leukemia.

Authors:  Maurizio Cavallari; Francesco Cavazzini; Antonio Cuneo; Gian Matteo Rigolin; Antonella Bardi; Eleonora Volta; Aurora Melandri; Elisa Tammiso; Elena Saccenti; Enrico Lista; Francesca Maria Quaglia; Antonio Urso; Michele Laudisi; Elisa Menotti; Luca Formigaro; Melissa Dabusti; Maria Ciccone; Paolo Tomasi; Massimo Negrini
Journal:  Oncotarget       Date:  2018-09-28

8.  Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study.

Authors:  Alexander C Leeksma; Panagiotis Baliakas; Theodoros Moysiadis; Anna Puiggros; Karla Plevova; Anne-Marie Van der Kevie-Kersemaekers; Hidde Posthuma; Ana E Rodriguez-Vicente; Anh Nhi Tran; Gisela Barbany; Larry Mansouri; Rebeqa Gunnarsson; Helen Parker; Eva Van den Berg; Mar Bellido; Zadie Davis; Meaghan Wall; Ilaria Scarpelli; Anders Österborg; Lotta Hansson; Marie Jarosova; Paolo Ghia; Pino Poddighe; Blanca Espinet; Sarka Pospisilova; Constantine Tam; Loïc Ysebaert; Florence Nguyen-Khac; David Oscier; Claudia Haferlach; Jacqueline Schoumans; Marian Stevens-Kroef; Eric Eldering; Kostas Stamatopoulos; Richard Rosenquist; Jonathan C Strefford; Clemens Mellink; Arnon P Kater
Journal:  Haematologica       Date:  2021-01-01       Impact factor: 9.941

9.  The complex karyotype landscape in chronic lymphocytic leukemia allows the refinement of the risk of Richter syndrome transformation.

Authors:  Andrea Visentin; Laura Bonaldi; Gian Matteo Rigolin; Francesca Romana Mauro; Annalisa Martines; Federica Frezzato; Stefano Pravato; Leila Romano Gargarella; Maria Antonella Bardi; Maurizio Cavallari; Eleonora Volta; Francesco Cavazzini; Mauro Nanni; Monica Facco; Francesco Piazza; Anna Guarini; Robin Foà; Gianpietro Semenzato; Antonio Cuneo; Livio Trentin
Journal:  Haematologica       Date:  2022-04-01       Impact factor: 9.941

10.  Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients.

Authors:  Silvia Ramos-Campoy; Anna Puiggros; Sílvia Beà; Sandrine Bougeon; María José Larráyoz; Dolors Costa; Helen Parker; Gian Matteo Rigolin; Margarita Ortega; María Laura Blanco; Rosa Collado; Rocío Salgado; Tycho Baumann; Eva Gimeno; Carolina Moreno; Francesc Bosch; Xavier Calvo; María José Calasanz; Antonio Cuneo; Jonathan C Strefford; Florence Nguyen-Khac; David Oscier; Claudia Haferlach; Jacqueline Schoumans; Blanca Espinet
Journal:  Haematologica       Date:  2022-03-01       Impact factor: 9.941
  10 in total

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