Rahel Befekadu1, Kjeld Christiansen2, Anders Larsson3, Magnus Grenegård4. 1. Department of Laboratory Medicine, Section for Transfusion Medicine, Faculty of Medicine and Health Örebro University, Örebro, Sweden. rshiferaw@hotmail.com. 2. Department of Cardiology, Örebro University Hospital, Örebro, Sweden. 3. Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 4. Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Örebro, Sweden.
Abstract
BACKGROUND: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischem-ic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1-3 days after and 3 months after percutanous coronary intervention (PCI). RESULTS: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed cul-prit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1. CONCLUSIONS: Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.
BACKGROUND: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischem-ic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1-3 days after and 3 months after percutanous coronary intervention (PCI). RESULTS: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed cul-prit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1. CONCLUSIONS:Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.
Authors: Yiannis S Chatzizisis; Aaron B Baker; Galina K Sukhova; Konstantinos C Koskinas; Michail I Papafaklis; Roy Beigel; Michael Jonas; Ahmet U Coskun; Benjamin V Stone; Charles Maynard; Guo-Ping Shi; Peter Libby; Charles L Feldman; Elazer R Edelman; Peter H Stone Journal: Circulation Date: 2011-01-31 Impact factor: 29.690
Authors: Kristian Wachtell; Bo Lagerqvist; Göran K Olivecrona; Stefan K James; Ole Fröbert Journal: Curr Cardiol Rep Date: 2016-01 Impact factor: 2.931
Authors: R de Nooijer; I Bot; J H von der Thüsen; M A Leeuwenburgh; H S Overkleeft; A O Kraaijeveld; R Dorland; P J van Santbrink; S H van Heiningen; M M Westra; P T Kovanen; J W Jukema; E E van der Wall; Th J C van Berkel; G P Shi; E A L Biessen Journal: Arterioscler Thromb Vasc Biol Date: 2008-12-18 Impact factor: 8.311
Authors: Sunny Goel; Avraham Miller; Chirag Agarwal; Elina Zakin; Michael Acholonu; Umesh Gidwani; Abhishek Sharma; Guy Kulbak; Jacob Shani; On Chen Journal: Radiol Res Pract Date: 2015-12-20