Qi Bao1, Ran Lv1, Min Lei2. 1. Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China. 2. Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China. leimin2017@zju.edu.cn.
Abstract
OBJECTIVE AND DESIGN: Sepsis remains a major clinical problem with high morbidity and mortality. Interleukin (IL)-33 is a recently described member of the IL-1 family that is widely expressed and functions as a new inflammatory mediator. IL-33 has been reported to protect sepsis, but the underlying mechanisms are not well-elucidated. MATERIALS AND METHODS: We measured the interferon gamma (IFN-γ) production in septic mice after IL-33 treatment. RESULTS: IL-33 treatment enhanced the IFN-γ level in blood and promoted mice's survival, so the protective effects of IL-33 depend on IFN-γ. The IL-33 treatment also promoted both γδ T cells and NK cells in septic mice. CONCLUSION: Our data showed that IL-33 attenuates mortality by promoting IFN-γ production in sepsis.
OBJECTIVE AND DESIGN:Sepsis remains a major clinical problem with high morbidity and mortality. Interleukin (IL)-33 is a recently described member of the IL-1 family that is widely expressed and functions as a new inflammatory mediator. IL-33 has been reported to protect sepsis, but the underlying mechanisms are not well-elucidated. MATERIALS AND METHODS: We measured the interferon gamma (IFN-γ) production in septic mice after IL-33 treatment. RESULTS:IL-33 treatment enhanced the IFN-γ level in blood and promoted mice's survival, so the protective effects of IL-33 depend on IFN-γ. The IL-33 treatment also promoted both γδ T cells and NK cells in septic mice. CONCLUSION: Our data showed that IL-33 attenuates mortality by promoting IFN-γ production in sepsis.
Entities:
Keywords:
IFN-γ; IL-33; NK cells; Sepsis; γδ T cells
Authors: Jose C Alves-Filho; Fabiane Sônego; Fabricio O Souto; Andressa Freitas; Waldiceu A Verri; Maria Auxiliadora-Martins; Anibal Basile-Filho; Andrew N McKenzie; Damo Xu; Fernando Q Cunha; Foo Y Liew Journal: Nat Med Date: 2010-05-16 Impact factor: 53.440
Authors: Ivan Ramirez-Moral; Dana C Blok; Jochem H Bernink; M Isabel Garcia-Laorden; Sandrine Florquin; Louis Boon; Cornelis Van't Veer; Matthias Mack; Simona Saluzzo; Sylvia Knapp; Hergen Spits; Alex F de Vos; Tom van der Poll Journal: J Pathol Date: 2021-01-19 Impact factor: 7.996