Soufiane Ajana1, Daniela Weber2, Catherine Helmer1, Bénédicte M Merle1, Wolfgang Stuetz3, Jean-François Dartigues1,4, Marie-Bénédicte Rougier5, Jean-François Korobelnik1,5, Tilman Grune2, Cécile Delcourt1, Catherine Féart1. 1. University of Bordeaux, Institut National de la Sante et de la Recherche Medicale (INSERM), Bordeaux Population Health Research Center, Team LEHA, Bordeaux, France. 2. Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. 3. Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany. 4. Bordeaux University Hospital, Memory Consultation, Centre Mémoire de Ressources et de Recherche (CMRR), Bordeaux, France. 5. Ophthalmology Department, Centre Hospitalier Universitaire (CHU) of Bordeaux, Bordeaux, France.
Abstract
Purpose: We investigated the cross-sectional associations between macular pigment optical density (MPOD), plasma lutein (L), and zeaxanthin (Z) concentrations and cognitive function in 184 older adults of the 3-City-Bordeaux cohort. Methods: MPOD was measured using the two-wavelength autofluorescence method with a modified scanning laser ophthalmoscope. Plasma L and Z (L+Z) concentrations were determined by high-performance liquid chromatography and were considered either crude or expressed as a ratio of the concentration of plasma lipids (total cholesterol [TC] + triglycerides [TG]). Cognitive performances were assessed using the following four separate neuropsychological tests: the Mini-Mental State Examination (MMSE), the Isaacs Set Test (IST), the Benton Visual Retention Test (BVRT), and the sum of the three free recalls of the Free and Cued Selective Reminding Test (FCSRT). These test results were summarized by a composite global cognitive z-score. Results: Higher MPOD at 0.5° was significantly associated with a higher composite z-score (β = 0.15, 95% confidence interval [CI] 0.04-0.26), higher BVRT (β = 0.39, 95%CI 0.08-0.70), and higher IST (β = 1.16, 95%CI 0.11-2.22) performances. Higher plasma L+Z concentrations were significantly associated with higher IST scores (β = 0.97, 95%CI 0.01-1.94). Furthermore, a higher L+Z/TC+TG ratio was associated with a higher composite z-score (β = 0.12, 95%CI 0.01-0.23), along with higher IST (β = 1.02, 95%CI 0.002-2.04) and FCSRT (β = 1.55, 95%CI 0.41-2.69) performances. Conclusions: This analysis suggested that both higher MPOD and L+Z concentrations were significantly associated with higher cognitive performances. However, MPOD measurements have the advantage of being a fast and representative measure of long-term carotenoid intake.
Purpose: We investigated the cross-sectional associations between macular pigment optical density (MPOD), plasma lutein (L), and zeaxanthin (Z) concentrations and cognitive function in 184 older adults of the 3-City-Bordeaux cohort. Methods: MPOD was measured using the two-wavelength autofluorescence method with a modified scanning laser ophthalmoscope. Plasma L and Z (L+Z) concentrations were determined by high-performance liquid chromatography and were considered either crude or expressed as a ratio of the concentration of plasma lipids (total cholesterol [TC] + triglycerides [TG]). Cognitive performances were assessed using the following four separate neuropsychological tests: the Mini-Mental State Examination (MMSE), the Isaacs Set Test (IST), the Benton Visual Retention Test (BVRT), and the sum of the three free recalls of the Free and Cued Selective Reminding Test (FCSRT). These test results were summarized by a composite global cognitive z-score. Results: Higher MPOD at 0.5° was significantly associated with a higher composite z-score (β = 0.15, 95% confidence interval [CI] 0.04-0.26), higher BVRT (β = 0.39, 95%CI 0.08-0.70), and higher IST (β = 1.16, 95%CI 0.11-2.22) performances. Higher plasma L+Z concentrations were significantly associated with higher IST scores (β = 0.97, 95%CI 0.01-1.94). Furthermore, a higher L+Z/TC+TG ratio was associated with a higher composite z-score (β = 0.12, 95%CI 0.01-0.23), along with higher IST (β = 1.02, 95%CI 0.002-2.04) and FCSRT (β = 1.55, 95%CI 0.41-2.69) performances. Conclusions: This analysis suggested that both higher MPOD and L+Z concentrations were significantly associated with higher cognitive performances. However, MPOD measurements have the advantage of being a fast and representative measure of long-term carotenoid intake.
Authors: Regan L Bailey; Tieraona Low Dog; Abbie E Smith-Ryan; Sai Krupa Das; Fiona C Baker; Zeynep Madak-Erdogan; Billy R Hammond; Howard D Sesso; Alex Eapen; Susan H Mitmesser; Andrea Wong; Haiuyen Nguyen Journal: J Nutr Date: 2022-07-06 Impact factor: 4.687
Authors: Niranjani Nagarajan; Lama Assi; V Varadaraj; Mina Motaghi; Yi Sun; Elizabeth Couser; Joshua R Ehrlich; Heather Whitson; Bonnielin K Swenor Journal: BMJ Open Date: 2022-01-06 Impact factor: 3.006