Veronica Ojetti 1 , Carmine Petruzziello 1 , Silvia Cardone 1 , Luisa Saviano 1 , Alessio Migneco 1 , Luca Santarelli 1 , Maurizio Gabrielli 1 , Raffaella Zaccaria 1 , Loris Lopetuso 2 , Marcello Covino 1 , Marcello Candelli 1 , Antonio Gasbarrini 2 , Francesco Franceschi 1 Show Affiliations »
Abstract
BACKGROUND & AIMS: Diverticular Disease (DD) is a common clinical condition with a dramatic increasing of the prevalence among industrialized countries. Based on the most used classification, DD may be divided into asymptomatic diverticulosis, symptomatic uncomplicated diverticular disease and complicated diverticular disease. Since recent studies pointed out the role of GUT microbiota imbalance in promoting diverticular formation and inflammation, we have designed a systematic review focusing on the possible role of probiotics in the management of this condition. METHODS: According to PRISMA, we identified studies on DD patients treated with probiotics, by searching on Pubmed, Embase, Cochrane and ResearchGate. RESULTS: 13 studies were included in this review based on our selection criteria: 3 double-blind randomized placebo-controlled, 6 open randomized, and 4 non-randomized open studies. CONCLUSION: This is the first systematic review providing an updated measure of evidence on the efficacy of probiotics in a different phase of DD. Even though the majority of studies are still preliminary, current data show a possible clinical application of certain probiotic strains in all stages of DD. Further investigation is then required to better understand when and how probiotics can be used in different phases of DD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND & AIMS: Diverticular Disease (DD) is a common clinical condition with a dramatic increasing of the prevalence among industrialized countries. Based on the most used classification, DD may be divided into asymptomatic diverticulosis , symptomatic uncomplicated diverticular disease and complicated diverticular disease . Since recent studies pointed out the role of GUT microbiota imbalance in promoting diverticular formation and inflammation , we have designed a systematic review focusing on the possible role of probiotics in the management of this condition. METHODS: According to PRISMA, we identified studies on DD patients treated with probiotics, by searching on Pubmed, Embase, Cochrane and ResearchGate. RESULTS: 13 studies were included in this review based on our selection criteria: 3 double-blind randomized placebo-controlled, 6 open randomized, and 4 non-randomized open studies. CONCLUSION: This is the first systematic review providing an updated measure of evidence on the efficacy of probiotics in a different phase of DD. Even though the majority of studies are still preliminary, current data show a possible clinical application of certain probiotic strains in all stages of DD. Further investigation is then required to better understand when and how probiotics can be used in different phases of DD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Species
Keywords:
Diverticular disease; GUT microbiota imbalance; PRISMA; probiotics; remission; review.
Mesh： See more »
Year: 2018
PMID： 29607785 DOI： 10.2174/1574887113666180402143140
Source DB: PubMed Journal: Rev Recent Clin Trials ISSN： 1574-8871