| Literature DB >> 29607300 |
An Verdoodt1, Patrick M Honore2, Rita Jacobs1, Elisabeth De Waele1, Viola Van Gorp1, Jouke De Regt1, Herbert D Spapen1.
Abstract
Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to its ability to control cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabilizing activity. Along this line, statins may also exert acute and long-term effects on renal function. We present a narrative literature review that summarizes arguments in favor of or against the preventive and/or therapeutic use of statins in kidney-related diseases or complications. We also highlight the ongoing controversy regarding statin therapy in chronic and end-stage kidney disease.Entities:
Keywords: acute kidney injury; cardiorenal syndrome; chronic kidney disease; contrast-induced nephropathy; end-stage renal disease; rhabdomyolysis; statins
Year: 2018 PMID： 29607300 PMCID： PMC5874483 DOI： 10.2478/jtim-2018-0005
Source DB: PubMed Journal: J Transl Int Med ISSN： 2224-4018