Yoonju Lee1, Yeong-Hun Park2, Jae Jung Lee3, Young H Sohn1, Jong-Min Lee4, Phil Hyu Lee5. 1. Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemungu, Seoul 03722, South Korea. 2. Department of Biomedical Engineering, Hanyang University, 222 Wangsimni-ro, Sungdong-gu, Seoul 04763, South Korea. 3. Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang 10380, South Korea. 4. Department of Biomedical Engineering, Hanyang University, 222 Wangsimni-ro, Sungdong-gu, Seoul 04763, South Korea. Electronic address: jmlee@bme.hanyang.ac.kr. 5. Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemungu, Seoul 03722, South Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Electronic address: phlee@yuhs.ac.
Abstract
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD. METHODS: This study enrolled 135 de novo patients with PD underwent functional magnetic resonance imaging (MRI). Based on the distribution, the serum UA level was stratified into tertiles in the PD patients by gender. With a seed-based approach, we investigated the pattern of RSN within the dorsal attention network (DAN), executive control network (ECN), and default mode network (DMN). RESULTS: Interaction analysis showed a significant interaction between the lowest (PD-L-UA) and the highest UA level (PD-H-UA) groups according to gender within the DAN, ECN, and DMN. Compared to the control subjects, male patients with PD-H-UA had higher cortical functional connectivity (FC), while female patients had lower cortical FC regardless of UA level within all seeds. In a direct comparison, male patients with PD-H-UA had increased FC than did those with PD-L-UA. However, there was no significant difference in FC between PD-L-UA and PD-H-UA in female PD patients. CONCLUSIONS: These data suggest that RSN might be closely and gender-specifically associated with the status of serum UA in de novo PD patients.
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD. METHODS: This study enrolled 135 de novo patients with PD underwent functional magnetic resonance imaging (MRI). Based on the distribution, the serum UA level was stratified into tertiles in the PDpatients by gender. With a seed-based approach, we investigated the pattern of RSN within the dorsal attention network (DAN), executive control network (ECN), and default mode network (DMN). RESULTS: Interaction analysis showed a significant interaction between the lowest (PD-L-UA) and the highest UA level (PD-H-UA) groups according to gender within the DAN, ECN, and DMN. Compared to the control subjects, male patients with PD-H-UA had higher cortical functional connectivity (FC), while female patients had lower cortical FC regardless of UA level within all seeds. In a direct comparison, male patients with PD-H-UA had increased FC than did those with PD-L-UA. However, there was no significant difference in FC between PD-L-UA and PD-H-UA in female PDpatients. CONCLUSIONS: These data suggest that RSN might be closely and gender-specifically associated with the status of serum UA in de novo PDpatients.