Literature DB >> 2960547

Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways.

J R Lamb1, E D Zanders, W Sewell, M J Crumpton, M Feldmann, M J Owen.   

Abstract

We have investigated the role of the CD2 protein in the negative regulation of immune function and report that similar to antigen and anti-CD3, the monoclonal anti-CD2 antibodies (T112 and T113) can induce specific unresponsiveness. Antigen and anti-CD2 tolerogenic signals both down-regulated the phenotypic expression of CD3-Ti. In contrast CD2 surface expression was up-regulated after exposure to peptide and down-regulated after anti-T112 and T113 preincubation. However, in both instances interleukin 2 receptor surface levels were increased. These phenotypic changes could only be partly explained by variations in the levels of the transcripts encoding the CD3-Ti and CD2 molecules.

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Year:  1987        PMID： 2960547     DOI： 10.1002/eji.1830171118

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  6 in total

1.  Lymphocyte sensitization to Aspergillus fumigatus in allergic bronchopulmonary aspergillosis.

Authors:  C A Walker; P Fitzharris; J L Longbottom; A J Taylor
Journal:  Clin Exp Immunol       Date:  1989-04       Impact factor: 4.330

2.  A multimeric form of soluble recombinant sheep LFA-3 (CD58) inhibits human T-cell proliferation.

Authors:  K Yamashita; C R Parish; H S Warren; L C Harrison
Journal:  Immunology       Date:  1997-09       Impact factor: 7.397

3.  The phenotypic and molecular characterization of Nb2 lymphoma cells activated with IL-2 and human growth hormone.

Authors:  J H Cox; J R Lamb; V Bal; G W Butcher; J C Howard; M J Owen; J Ivanyi
Journal:  Immunology       Date:  1989-01       Impact factor: 7.397

4.  Immune deviation in the mouse: transfer of selective depression of the contact sensitivity and interleukin-2 response with retention of interferon-gamma production requires CD8+ T cells.

Authors:  G L Asherson; F Dieli
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

5.  Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

Authors:  G Essery; M Feldmann; J R Lamb
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

6.  Anti-CD2 antibodies induce T cell unresponsiveness in vivo.

Authors:  B Gückel; C Berek; M Lutz; P Altevogt; V Schirrmacher; B A Kyewski
Journal:  J Exp Med       Date:  1991-11-01       Impact factor: 14.307
  6 in total

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