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Literature DB >> 29605062

Genetic Vulnerability of GPCRs: A Call to Action.

Abstract

G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The 'one-drug-fits-all' approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.

Entities: Chemical Disease Gene Species

Keywords: G protein; asthma; coupling; heart failure; mutation; polymorphism

Mesh：

Substances：

Year: 2018 PMID： 29605062 PMCID： PMC6092946 DOI： 10.1016/j.tibs.2018.02.006

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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References

10 in total

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Authors: Stephen B Liggett; Jeanne Mialet-Perez; Surai Thaneemit-Chen; Stewart A Weber; Scott M Greene; Danielle Hodne; Bradley Nelson; Jennifer Morrison; Michael J Domanski; Lynne E Wagoner; William T Abraham; Jeffrey L Anderson; John F Carlquist; Heidi J Krause-Steinrauf; Laura C Lazzeroni; J David Port; Philip W Lavori; Michael R Bristow
Journal: Proc Natl Acad Sci U S A Date: 2006-07-14 Impact factor: 11.205

Genetic Vulnerability of GPCRs: A Call to Action.

1. Pharmacogenetic applications of the Human Genome project.

Review 2. Pharmacology and physiology of human adrenergic receptor polymorphisms.

3. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure.

4. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.

5. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.

6. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.

7. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.

8. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.

9. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily.

10. Pharmacogenomics of GPCR Drug Targets.