Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 YY1 Is an Inducer of Cancer Metastasis.

Literature DB >> 29604932

YY1 Is an Inducer of Cancer Metastasis.

Wenmeng Wang¹, Dangdang Li¹, Guangchao Sui².

Abstract

Yin Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins that plays vital roles in many biological processes, especially tumorigenesis. To date, ample evidence suggests a critical regulatory role of YY1 in tumor cell metastasis. The potential of YY1 as a valuable biomarker for cancer metastasis has been increasingly known. Here, we review the studies related to the expression, regulatory network, and clinical application of YY1 in cancer metastasis. We first summarize YY1 expression patterns in metastatic tumors. We then elaborate YY1-regulated mechanisms on five aspects, including epithelial-mesenchymal transition, cell migration and invasion, stemness, polyploidy, and genomic stability. Finally, we discuss the correlation between YY1 expression and clinical outcomes and therapeutic potential of YY1 in cancer treatment. Based on this review, we conclude that YY1 is a bona fide inducer of cancer metastasis and can serve as a clinical biomarker and therapeutic target for cancer treatment.

Entities: Disease Gene

Mesh：

Substances：
YY1 Transcription Factor

Year: 2017 PMID： 29604932 DOI： 10.1615/CritRevOncog.2017021314

Source DB: PubMed Journal: Crit Rev Oncog ISSN： 0893-9675

Keyword Cloud
Cited

10 in total

1. A cis-element within the ARF locus mediates repression of p16 ^INK4A expression via long-range chromatin interactions.

Authors: Yang Zhang; Judith Hyle; Shaela Wright; Ying Shao; Xujie Zhao; Hui Zhang; Chunliang Li
Journal: Proc Natl Acad Sci U S A Date: 2019-12-09 Impact factor: 11.205

2. Yin Yang 1-induced activation of LINC01133 facilitates the progression of pancreatic cancer by sponging miR-199b-5p to upregulate myelin regulatory factor expression.

Authors: Xi Yang; Leiming Wang; Fei Zhou; Song Ye; Qianghu Sun
Journal: Bioengineered Date: 2022-05 Impact factor: 6.832

Review 3. YY1 Is a Key Player in Melanoma Immunotherapy/Targeted Treatment Resistance.

Authors: Dominika Kwiatkowska; Ewelina Mazur; Adam Reich
Journal: Front Oncol Date: 2022-06-01 Impact factor: 5.738

4. YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates.

Authors: Divya Bhaskar Rao; Ponmathi Panneerpandian; Karthik Balakrishnan; Kumaresan Ganesan
Journal: J Cell Commun Signal Date: 2021-02-23 Impact factor: 5.782

5. YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.

Authors: Chengjie Mei; Xiang Jiang; Yang Gu; Xiaoling Wu; Weijie Ma; Xi Chen; Ganggang Wang; Ye Yao; Yingyi Liu; Zhonglin Zhang; Yufeng Yuan
Journal: Am J Cancer Res Date: 2021-05-15 Impact factor: 6.166

6. Deficiency of Wiskott-Aldrich syndrome protein has opposing effect on the pro-oncogenic pathway activation in nonmalignant versus malignant lymphocytes.

Authors: Seong-Su Han; Kuo-Kuang Wen; Yatin M Vyas
Journal: Oncogene Date: 2020-11-02 Impact factor: 9.867

YY1 Is an Inducer of Cancer Metastasis.

1. A cis-element within the ARF locus mediates repression of p16 ^INK4A expression via long-range chromatin interactions.

2. Yin Yang 1-induced activation of LINC01133 facilitates the progression of pancreatic cancer by sponging miR-199b-5p to upregulate myelin regulatory factor expression.

Review 3. YY1 Is a Key Player in Melanoma Immunotherapy/Targeted Treatment Resistance.

4. YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates.

5. YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.

6. Deficiency of Wiskott-Aldrich syndrome protein has opposing effect on the pro-oncogenic pathway activation in nonmalignant versus malignant lymphocytes.

7. YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins.

Review 8. Advances of Zinc Signaling Studies in Prostate Cancer.

Review 9. The biological implications of Yin Yang 1 in the hallmarks of cancer.

Review 10. Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells.

YY1 Is an Inducer of Cancer Metastasis.

1. A cis-element within the ARF locus mediates repression of p16 INK4A expression via long-range chromatin interactions.

2. Yin Yang 1-induced activation of LINC01133 facilitates the progression of pancreatic cancer by sponging miR-199b-5p to upregulate myelin regulatory factor expression.

Review 3. YY1 Is a Key Player in Melanoma Immunotherapy/Targeted Treatment Resistance.

4. YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates.

5. YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.

6. Deficiency of Wiskott-Aldrich syndrome protein has opposing effect on the pro-oncogenic pathway activation in nonmalignant versus malignant lymphocytes.

7. YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins.

Review 8. Advances of Zinc Signaling Studies in Prostate Cancer.

Review 9. The biological implications of Yin Yang 1 in the hallmarks of cancer.

Review 10. Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells.

1. A cis-element within the ARF locus mediates repression of p16 ^INK4A expression via long-range chromatin interactions.