Marcela Mercado1, Jorge Acosta-Reyes2, Edgar Parra3, Luis Guzmán4, Mauricio Beltrán3, Philippe Gasque5, Carlos Mejía-García6, Diego Viasus7. 1. Division of Research in Public Health, National Institute of Health of Colombia, Bogota, Colombia. 2. Division of Health Sciences, Department of Public Health, Universidad del Norte, Barranquilla, Colombia. 3. Direction of Public Health Networks, Virology and Pathology Laboratories, National Institute of Health of Colombia, Bogotá, Colombia. 4. Division of Health Sciences, Faculty of Medicine, Universidad del Norte and Hospital Universidad del Norte, Barranquilla, Colombia. 5. UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical, Université de la Réunion, INSERM 1187, CNRS 9192, IRD 249, Saint-Denis, la Réunion, France. 6. Division of Nephrology, Direction of Foundation Prevrenal, Cali, Colombia. 7. Division of Health Sciences, Faculty of Medicine, Universidad del Norte and Hospital Universidad del Norte, Barranquilla, Colombia. Electronic address: dviasus@uninorte.edu.co.
Abstract
BACKGROUND: Information regarding physiopathology and complications in fatal cases of chikungunya virus (CHIKV) is scarce. OBJECTIVES: The aim of this study was to describe the frequency and severity of renal complications in fatal cases associated with CHIKV infection based on the clinical and histopathological features from post-mortem tissue biopsies. STUDY DESIGN: This retrospective study included fatal cases associated with CHIKV infection occurring from September 2014 through October 2015, reported to National System for Public Health Surveillance (SIVIGILA) and laboratory-confirmed by the National Institute of Health of Colombia. Medical records from 13 patients were available. Information was collected on history, physical examination, and haematological, biochemical, radiological, and virologic investigation reports. RESULTS: Diagnosis of CHIKV infection was performed by positive CHIKV-PCR on post-mortem tissue in 10 cases, positive CHIKV-PCR in serum in 6 cases and anti-CHIKV virus IgM in 2 cases. Only 3 cases were children (≤5 years old). Four cases had underlying diseases, mainly systemic arterial hypertension. The median value of creatinine at admission was 2.8 mg/dL (interquartile range 1.52-4.51). During hospitalization, 9 cases required ICU admission, 8 vasopressor support and 6 mechanical ventilation. Kidney histopathological findings were mainly acute interstitial nephritis (11 cases), congestion/oedema glomerular (10 cases) and acute tubular necrosis (5 cases). CONCLUSIONS: Renal impairment in fatal cases of CHIKV infection is frequent and related mainly to acute interstitial nephritis. These data demonstrate evidence of acquired kidney injuries during CHIKV infection.
BACKGROUND: Information regarding physiopathology and complications in fatal cases of chikungunya virus (CHIKV) is scarce. OBJECTIVES: The aim of this study was to describe the frequency and severity of renal complications in fatal cases associated with CHIKV infection based on the clinical and histopathological features from post-mortem tissue biopsies. STUDY DESIGN: This retrospective study included fatal cases associated with CHIKV infection occurring from September 2014 through October 2015, reported to National System for Public Health Surveillance (SIVIGILA) and laboratory-confirmed by the National Institute of Health of Colombia. Medical records from 13 patients were available. Information was collected on history, physical examination, and haematological, biochemical, radiological, and virologic investigation reports. RESULTS: Diagnosis of CHIKV infection was performed by positive CHIKV-PCR on post-mortem tissue in 10 cases, positive CHIKV-PCR in serum in 6 cases and anti-CHIKV virus IgM in 2 cases. Only 3 cases were children (≤5 years old). Four cases had underlying diseases, mainly systemic arterial hypertension. The median value of creatinine at admission was 2.8 mg/dL (interquartile range 1.52-4.51). During hospitalization, 9 cases required ICU admission, 8 vasopressor support and 6 mechanical ventilation. Kidney histopathological findings were mainly acute interstitial nephritis (11 cases), congestion/oedema glomerular (10 cases) and acute tubular necrosis (5 cases). CONCLUSIONS:Renal impairment in fatal cases of CHIKV infection is frequent and related mainly to acute interstitial nephritis. These data demonstrate evidence of acquired kidney injuries during CHIKV infection.
Authors: Geraldo Bezerra da Silva Junior; José Reginaldo Pinto; Rosa Maria Salani Mota; Roberto da Justa Pires Neto; Elizabeth De Francesco Daher Journal: Am J Trop Med Hyg Date: 2018-11 Impact factor: 2.345
Authors: Rhaquel de Morais Alves Barbosa Oliveira; Francisca Kalline de Almeida Barreto; Geovana Praça Pinto; Isabella Timbó Queiroz; Fernanda Montenegro de Carvalho Araújo; Kilma Wanderley Lopes; Regina Lúcia Sousa do Vale; Daniele Rocha Queiroz Lemos; John Washington Cavalcante; André Machado Siqueira; Lívia Carla Vinhal Frutuoso; Elisabeth Carmen Duarte; Antônio Silva Lima Neto; André Ricardo Ribas Freitas; Luciano Pamplona de Góes Cavalcanti Journal: PLoS One Date: 2022-04-07 Impact factor: 3.240