C Labbe1, C Delesalle2, C Creveuil3, M Dreyfus4. 1. Service de gynécologie-obstétrique et médecine de la reproduction, CHU, bâtiment FEH, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France. Electronic address: labbe-c@chu-caen.fr. 2. Service de gynécologie-obstétrique et médecine de la reproduction, CHU, bâtiment FEH, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France. 3. Unité de biostatistique et de recherche clinique, CHU, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France; Université de Caen-Normandie, UFR médecine, esplanade de la Paix, 14032 Caen cedex 5, France. 4. Service de gynécologie-obstétrique et médecine de la reproduction, CHU, bâtiment FEH, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France; Université de Caen-Normandie, UFR médecine, esplanade de la Paix, 14032 Caen cedex 5, France.
Abstract
OBJECTIVE: To compare the risk for adverse pregnancy and fetal outcomes in early or late-onset intrahepatic cholestasis of pregnancy (ICP). METHODS: In a retrospective and unicentric analysis, data were collected for all women with ICP (serum bile acid level over 8mol/L) between June 1, 2008 and January 1, 2015. Patients were divided in early-onset ICP (pregnancy duration at diagnosis<33 weeks) and late-onset ICP (pregnancy duration at diagnosis≥33 weeks). The frequency of adverse pregnancy and fetal outcomes was assessed. RESULTS: Among 138 eligible women, 40 were in the early-onset group and 98 in the late-onset group. Adverse pregnancy or fetal outcomes affected significantly more patients in early-onset ICP group (45% versus 17.3%, P<0.05). Threatened preterm birth (30% versus 10.0%, P<0.05) was significantly increased in early-onset ICP group. Prematurity was higher in early-onset group (40.0% versus 28.0%, P=0.23). Early-onset and severe ICP were not significantly linked (P=0.16). CONCLUSION: Early-onset ICP diagnosed before 33 Weeks is associated with adverse pregnancy outcomes, particularly threatened preterm birth.
OBJECTIVE: To compare the risk for adverse pregnancy and fetal outcomes in early or late-onset intrahepatic cholestasis of pregnancy (ICP). METHODS: In a retrospective and unicentric analysis, data were collected for all women with ICP (serum bile acid level over 8mol/L) between June 1, 2008 and January 1, 2015. Patients were divided in early-onset ICP (pregnancy duration at diagnosis<33 weeks) and late-onset ICP (pregnancy duration at diagnosis≥33 weeks). The frequency of adverse pregnancy and fetal outcomes was assessed. RESULTS: Among 138 eligible women, 40 were in the early-onset group and 98 in the late-onset group. Adverse pregnancy or fetal outcomes affected significantly more patients in early-onset ICP group (45% versus 17.3%, P<0.05). Threatened preterm birth (30% versus 10.0%, P<0.05) was significantly increased in early-onset ICP group. Prematurity was higher in early-onset group (40.0% versus 28.0%, P=0.23). Early-onset and severe ICP were not significantly linked (P=0.16). CONCLUSION: Early-onset ICP diagnosed before 33 Weeks is associated with adverse pregnancy outcomes, particularly threatened preterm birth.
Authors: Anastasia A Salame; Mohammad J Jaffal; Marco A Mouanness; Amal R Nasser Eddin; Labib M Ghulmiyyah Journal: Case Rep Obstet Gynecol Date: 2019-12-27