Hyung Oh Kim1, Jae-Min Kim1, Jong Shin Woo1, Donghoon Choi2, Young-Guk Ko2, Chul-Min Ahn2, Seung-Whan Lee3, Jae-Hwan Lee4, Seung-Hyuk Choi5, Cheol Woong Yu6, Pil-Ki Min7, Chang-Hwan Yoon8, In-Ho Chae8, Sang-Rok Lee9, Yoon Seok Koh10, Weon Kim11. 1. Division of Cardiology, Kyung Hee University, Republic of Korea. 2. Severance Hospital, Seoul, Division of Cardiology, Seoul, Republic of Korea. 3. Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Department of Medical Science, Chungnam National University, Republic of Korea. 5. Division of Cardiology, Samsung Medical Center, Republic of Korea. 6. Cardiology, Korea University Anam Hospital, Republic of Korea. 7. Division of Cardiology, Gangnam Severance Hospital, Republic of Korea. 8. Cardiovascular center, Seoul National University Bundang Hospital, Republic of Korea. 9. Division of Cardiology, Chonbuk National University Hospital, Republic of Korea. 10. Cardiology, The Catholic University of Korea, Seoul St. Mary's Hospital, Republic of Korea. 11. Division of Cardiology, Kyung Hee University, Republic of Korea. Electronic address: mylovekw@hanmail.net.
Abstract
OBJECTIVES: Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. METHODS: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT. Baseline characteristics, in-hospital events, and overall- and major adverse limb events (MALE)-free survival were analyzed. RESULTS: 2739 patients (3548 target limbs) were included. 272 patients featured CKD (9.9%). Limbs in CKD patients had higher Rutherford scores, higher prevalence of critical limb ischemia (CLI). There were no differences in technical success rates in non-CKD vs. CKD group comparison and non-severe CKD vs. severe CKD group comparison (p = 0.050, 0.581, respectively). In-hospital death (p < 0.001) and short-term unexpected amputation (p = 0.028) were more frequent in the CKD group. The short-term outcome differences between severe and non-severe CKD were insignificant. Kaplan-Meier curves favored overall and MALE-free survival in non-CKD patients compared with CKD patients, but there was no difference in overall- or MALE-free survival between non-severe CKD and severe CKD groups. CONCLUSION: PAD patients with CKD showed worse short-term mortality, short-term unexpected amputation outcome, and overall- and MALE-free survival than those without CKD in real EVT era. These findings might provide additive prognostic information for PAD patients with CKD who will be treated with EVT.
OBJECTIVES:Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. METHODS: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT. Baseline characteristics, in-hospital events, and overall- and major adverse limb events (MALE)-free survival were analyzed. RESULTS: 2739 patients (3548 target limbs) were included. 272 patients featured CKD (9.9%). Limbs in CKD patients had higher Rutherford scores, higher prevalence of critical limb ischemia (CLI). There were no differences in technical success rates in non-CKD vs. CKD group comparison and non-severe CKD vs. severe CKD group comparison (p = 0.050, 0.581, respectively). In-hospital death (p < 0.001) and short-term unexpected amputation (p = 0.028) were more frequent in the CKD group. The short-term outcome differences between severe and non-severe CKD were insignificant. Kaplan-Meier curves favored overall and MALE-free survival in non-CKD patients compared with CKD patients, but there was no difference in overall- or MALE-free survival between non-severe CKD and severe CKD groups. CONCLUSION: PAD patients with CKD showed worse short-term mortality, short-term unexpected amputation outcome, and overall- and MALE-free survival than those without CKD in real EVT era. These findings might provide additive prognostic information for PAD patients with CKD who will be treated with EVT.
Authors: E Hope Weissler; Yongfei Wang; Jordan M Gales; Dmitriy N Feldman; Shipra Arya; Eric A Secemsky; Herbert D Aronow; Beau M Hawkins; J Antonio Gutierrez; Manesh R Patel; Jeptha P Curtis; W Schuyler Jones; Rajesh V Swaminathan Journal: J Am Heart Assoc Date: 2022-06-20 Impact factor: 6.106