Marie Eliasen1, Andreas Schröder2, Per Fink2, Svend Kreiner3, Thomas Meinertz Dantoft4, Chalotte Heinsvig Poulsen5, Marie Weinreich Petersen2, Lene Falgaard Eplov6, Sine Skovbjerg7, Torben Jørgensen8. 1. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark. Electronic address: marie.holm.eliasen@regionh.dk. 2. Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark. 3. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 4. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark. 5. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Mental Health Centre Copenhagen, The Capital Region of Denmark, Hellerup, Denmark. 6. Mental Health Centre Copenhagen, The Capital Region of Denmark, Hellerup, Denmark. 7. Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark. 8. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Abstract
OBJECTIVES: The current delimitation of functional somatic syndromes (FSS) is inconsistent. We aimed to investigate somatic symptom profiles in the general adult population to contribute to a new, data-driven delimitation of FSS. METHODS: Information on 31 self-reported somatic symptoms used in the delimitation of various FSS and bodily distress syndrome (BDS) was obtained from the DanFunD study-a population-based cohort study on 9656 adults (participation 33.6%) from Greater Copenhagen, Denmark. Latent class analysis was used to identify symptom profiles. The profiles were described by their relation with sex, age, chronic disease, self-perceived health, symptom impact, self-reported FSS, and BDS case-status. RESULTS: Eight symptom profiles were identified. The largest profile had no symptoms (49% of the population). Three profiles were characterized by a few, specific symptoms: muscle and joint pain (17%), gastrointestinal symptoms (6%), and general symptoms (13%). Three profiles had multiple symptoms in specific combinations: musculoskeletal and general symptoms (7%); fatigue, musculoskeletal and gastrointestinal symptoms (3%); and cardiopulmonary, gastrointestinal and general symptoms (3%). Lastly, one profile (2%) had high probability of all symptoms. The last four profiles (15%) were strongly associated with BDS case-status, poor self-perceived health and high impact of symptoms. Analyses excluding persons with multi-symptomatic chronic disease showed similar results. CONCLUSIONS: We identified eight symptom profiles characterized by specific combinations of symptoms. Four of these had multiple symptoms from several bodily systems showing large overlap with BDS, possibly indicating subtypes of FSS. The profiles contribute to a new delimitation of FSS by illustrating the importance of specific symptom combinations.
OBJECTIVES: The current delimitation of functional somatic syndromes (FSS) is inconsistent. We aimed to investigate somatic symptom profiles in the general adult population to contribute to a new, data-driven delimitation of FSS. METHODS: Information on 31 self-reported somatic symptoms used in the delimitation of various FSS and bodily distress syndrome (BDS) was obtained from the DanFunD study-a population-based cohort study on 9656 adults (participation 33.6%) from Greater Copenhagen, Denmark. Latent class analysis was used to identify symptom profiles. The profiles were described by their relation with sex, age, chronic disease, self-perceived health, symptom impact, self-reported FSS, and BDS case-status. RESULTS: Eight symptom profiles were identified. The largest profile had no symptoms (49% of the population). Three profiles were characterized by a few, specific symptoms: muscle and joint pain (17%), gastrointestinal symptoms (6%), and general symptoms (13%). Three profiles had multiple symptoms in specific combinations: musculoskeletal and general symptoms (7%); fatigue, musculoskeletal and gastrointestinal symptoms (3%); and cardiopulmonary, gastrointestinal and general symptoms (3%). Lastly, one profile (2%) had high probability of all symptoms. The last four profiles (15%) were strongly associated with BDS case-status, poor self-perceived health and high impact of symptoms. Analyses excluding persons with multi-symptomatic chronic disease showed similar results. CONCLUSIONS: We identified eight symptom profiles characterized by specific combinations of symptoms. Four of these had multiple symptoms from several bodily systems showing large overlap with BDS, possibly indicating subtypes of FSS. The profiles contribute to a new delimitation of FSS by illustrating the importance of specific symptom combinations.
Authors: Marie Weinreich Petersen; Marianne Rosendal; Eva Ørnbøl; Per Fink; Torben Jørgensen; Thomas Meinertz Dantoft; Andreas Schröder Journal: BMJ Open Date: 2020-12-10 Impact factor: 2.692
Authors: Aki Vuokko; Kirsi Karvala; Hille Suojalehto; Harri Lindholm; Sanna Selinheimo; Marja Heinonen-Guzejev; Sami Leppämäki; Sebastian Cederström; Christer Hublin; Katinka Tuisku; Markku Sainio Journal: Saf Health Work Date: 2019-06-14
Authors: Marie Weinreich Petersen; Andreas Schröder; Torben Jørgensen; Eva Ørnbøl; Thomas Meinertz Dantoft; Marie Eliasen; Michael Eriksen Benros; Per Fink Journal: Sci Rep Date: 2020-02-24 Impact factor: 4.379
Authors: Marie Weinreich Petersen; Sine Skovbjerg; Jens Søndergaard Jensen; Tina Birgitte Wisbech Carstensen; Thomas Meinertz Dantoft; Per Fink; Michael Eriksen Benros; Erik Lykke Mortensen; Torben Jørgensen; Lise Kirstine Gormsen Journal: Eur J Pain Date: 2021-08-10 Impact factor: 3.651